Sökning: "dissociation constants"

Visar resultat 16 - 20 av 46 avhandlingar innehållade orden dissociation constants.

  1. 16. Biosensor Studies of Ligand Interactions with Structurally Flexible Enzymes : Applications for Antiviral Drug Development

    Författare :Matthis Geitmann; U. Helena Danielson; Marc H. V. van Regenmortel; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; SPR biosensor; HIV-1 reverse transcriptase; HCMV protease; interaction kinetics; drug discovery; non-nucleoside inhibitor; resistance; Biokemi; Biochemistry; Biokemi;

    Sammanfattning : The use of a surface plasmon biosensor fills a missing link in kinetic studies of enzymes, since it measures directly the interaction between biomolecules and allows determination of parameters that are determined only indirectly in activity assays. The present thesis deals with kinetic and dynamic aspects of ligand binding to two viral enzymes: the human cytomegalovirus (HCMV) protease and the human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT). LÄS MER

  3. 17. Synthesis and binding studies of 9,10-disubstituted anthracene and dibenzobarrelene-based receptors for recognition of carbohydrates in water

    Författare :Hans Grundberg; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organisk kemi; 2- trimethylsilyl ethyl sulfide; diastereoselectivity; water; carbohydrates; recognition; biomimetic; Artificial; receptor; Organic chemistry;

    Sammanfattning : Artificial, amfiphilic, and biomimetic receptors soluble in water were synthesized via attaching polar amino acids to hydrophobic back-bones possessing a surface suitable for hydrophobic interactions. The hydrophobic back-bones chosen in this thesis were anthracene and dibenzobarrelene structures. LÄS MER

  4. 18. Investigations of α-D-isosaccharinate: Fundamental Properties and Complexation

    Författare :Stefan Allard; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Waste products containing cellulose will be present in the planned underground radioactive waste repositories. It will be exposed to an alkaline environment for long periods of time. Under such conditions cellulose will degrade forming mainly isosaccharinate. LÄS MER

  5. 19. Signal Enhancement by Dynamic Polymers in Quartz Crystal Microbalance Applications

    Författare :Gunnar Dunér; Olof Ramström; Ian Nicholls; Andra Dedinaite; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Signal enhancement; QCM; polyelectrolytes; hydrogel; iniferter; photopolymerization; dynamic polymers; Chemistry; Kemi;

    Sammanfattning :  This licentiate thesis presents studies of signal enhancement by dynamic polymers in quartz crystal microbalance (QCM) applications. The aim of the study has been to determine the potential for the use of polymers on QCM sensors for signal enhancement in molecular interaction studies. LÄS MER

  7. 20. Development of miniaturised flow systems for wet chemical applications

    Författare :Karin Karlsson; Lennart Mathiasson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical Chemistry; analytisk kemi;

    Sammanfattning : This thesis is based on five papers addressing different types of analytical problems. In Papers I and II, the development of a miniaturised flow system is described as well as its use for monitoring compounds in industrial processes. LÄS MER