Sökning: "discrete response data"

Visar resultat 1 - 5 av 57 avhandlingar innehållade orden discrete response data.

  1. 1. Pharmacometric Methods and Novel Models for Discrete Data

    Författare :Elodie L Plan; Mats O Karlsson; Laura Sargentini-Maier; Armel Stockis; Christian Laveille; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; pharmacodynamics; disease progression; modelling; discrete data; count; ordered categorical; repeated time-to-event; RTTCE; RCEpT; NONMEM; FOCE; LAPLACE; SAEM; AGQ; pain scores; epilepsy seizures; gastroesophageal symptoms; statistical power; simulations; diagnostics; PHARMACY; FARMACI; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Sammanfattning : Pharmacodynamic processes and disease progression are increasingly characterized with pharmacometric models. However, modelling options for discrete-type responses remain limited, although these response variables are commonly encountered clinical endpoints. Types of data defined as discrete data are generally ordinal, e.g. LÄS MER

  3. 2. Pharmacometric Investigations of Prediction Precision and Advances of Models for Composite Scale Data

    Författare :Gustaf Wellhagen; Maria C. Kjellsson; Bengt Hamrén; Per Olsson Gisleskog; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; modelling; non-linear mixed effects modelling; composite scale data; total score data; total score analysis; precision prediction; bounded integer; bounded integer model; IRT-informed total score analysis; item response theory-informed; mixed models for repeated measures; MMRM; dose-response; dose-response mixed models for repeated measures; DR-MMRM; HbA1c models; fit-for-purpose analysis; clinical trial analysis; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Clinical trials are needed to evaluate new treatments. In late-stage clinical trials, failures are mostly due to lack of efficacy. Fit-for-purpose analysis methods will likely increase the success rates and advance drug development by providing higher precision to support decisions such as go/no-go, dose selection, or sample size. LÄS MER

  4. 3. Discrete Event Process Modeling of Manufacturing Systems Using Sensor Graphs

    Författare :Tord Alenljung; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; State Estimation; Fault Detection and Diagnosis; Process Modeling; Discrete Event Systems; Logic Controllers; Formal Verification; State Feedback Control;

    Sammanfattning : The design of control programs for manufacturing systemsis becoming more and more complex as the demands for flexibility,efficiency and reconfigurability increase, due tochanging consumer demands and fierce competition.There are methods stemming from academia that can assist the control programmersin facing these challenges. LÄS MER

  5. 4. Nonparametric tests for comparing two treatments by using ordinal data

    Författare :Helen Wahlström; Elisabeth Svensson; Jan Lanke; Sture Holm; Örebro universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Statistik; change; clinical trial; Monte Carlo; ordered categorical data; paired data; permutation test; Pitman efficiency; power; stratification; ties; visual analogue scale; Wilcoxon-Mann-Whitney statistic; statistik; Statistics; Statistik; Statistics; Statistik;

    Sammanfattning : This thesis concerns four nonparametric tests for comparing two treatments in a randomized controlled clinical trial when the main response variable generates discrete or continuous ordinal data and measurements are made at baseline and follow-up. In the Wilcoxon-Mann-Whitney test (WMW) the baseline values are not taken into account at all, but in the other three tests both baseline and follow-up values are used. LÄS MER

  7. 5. Essays on Unit-Root Testing and on Discrete-Response Modelling of Firm Mergers

    Författare :Nikolay Angelov; Per Johansson; Steinar Strøm; Uppsala universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Economics; unit root; structural break; LR test; stationary alternative; matching; firm mergers; discrete choice; Nationalekonomi; Economics; Nationalekonomi; nationalekonomi; Economics;

    Sammanfattning : Essay 1 investigates the time-series properties of the price of iron ore. The focus is on unit-root testing in the presence of a structural break. Unit-root tests with or without structural breaks are applied to historical prices of five different qualities of Swedish and Brazilian iron ore. Tests with exogenous or endogenous breaks are analyzed. LÄS MER