Sökning: "direct genomic value"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden direct genomic value.

  1. 1. Milk Genomics – Impact of Genetic Polymorphism on Bovine Milk Composition and Processability

    Författare :Maria Glantz; Livsmedelsteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; milk genomics; bovine milk; milk composition; technological properties; processability; cheese; quantitative genetic evaluation; single gene effect; genomic selection; genetic polymorphism; leptin; direct genomic value;

    Sammanfattning : Milk genomics is a new area of research that explores the relations between cow genetics and milk characteristics. Identifying the genes controlling compositional and technological traits of milk will give opportunities to select cows for targeted milk production. In this thesis, the impact of different genetic approaches, i.e. LÄS MER

  3. 2. High resolution genomic tools for the discovery of protein function in mammalian cells

    Författare :Emily Carol Hodges; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cell-based assays; overexpression; RNAi; BC2; C3F; Taxol;

    Sammanfattning : The work described in this thesis emphasizes the development of cell-based strategies with increased throughput design that enable rapid biological discovery through direct investigation of protein function. Each of the works represented in this thesis are unified by the common premise that genetic perturbations, through loss or gain-of-function, in cell-based models may serve as an entry point for assigning biological roles to uncharacterized genes and their gene products. LÄS MER

  4. 3. Pancreatic Cancer. Experimental and Clinical Studies

    Författare :David Ljungman; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pancreatic neoplasms; Proteasome inhibitors; Apoptosis; Intracellular signaling peptides and proteins; Epidermal growth factor receptor; Pancreaticoduodenectomy; Cost and cost analysis; Quality-adjusted life years; Copy number variations; Comparative genomic hybridization;

    Sammanfattning : Background: Pancreatic cancer is one of the most lethal of known cancers and the only treatment with possibility of cure is surgery. The costs associated with treatment of pancreatic cancer are reputably high, both in terms of morbidity and financially. LÄS MER

  5. 4. Colorectal cancer : genome, transcriptone and proteome dynamics

    Författare :Jens Karsten Habermann; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Colorectal carcinomas are the third most common malignancies in the Western World. Despite screening programs about 70% of these tumors are detected at advanced stages. Late diagnosis, however, results in a significant reduction of average survival times. LÄS MER

  7. 5. Lifestyle and glycaemic control before and after the onset of type 2 diabetes

    Författare :Robert Koivula; Genetisk och molekylär epidemiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 Diabetes; Prediabetes; Obesity; Beta-cell Function; Insulin Sensitivity; Physical Activity; Exercise; Diet; Lifestyle; Ectopic Fat; Genetic Epidemiology; Genetic Risk; Biomarker; Precision Medicine;

    Sammanfattning : Type 2 diabetes (T2D) is a complex disease with widespread physiological insults to the regulation of metabolic homeostasis, above all glycaemic regulation. The pathogenesis of T2D and its progression is broadly understood to be through a gradual decrease in peripheral insulin sensitivity, a compensatory rise in insulin secretion, and a gradual decline in beta-cell function, resulting in glycaemic dysregulation and eventual T2D. LÄS MER