Sökning: "direct crystallization"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden direct crystallization.

  1. 1. Crystallization of chiral compounds-Possibilities and limitations for resolution by direct crystallization

    Författare :Veronica Profir; KTH; []
    Nyckelord :metastable racemate; nucleation; solvent effect; solubility; direct crystallization; in situ IR spectroscopy; multivariate calibration;

    Sammanfattning : .... LÄS MER

  3. 2. On the separation of enantiomers by direct crystallization

    Författare :Veronica Profir; KTH; []
    Nyckelord :optical resolution; direct crystallization; threonine; mandelic acid; racemic compound; nucleation of metastable conglomerate; in situ concentration measurements; IR spectroscopy; multivariate calibration.;

    Sammanfattning : .... LÄS MER

  4. 3. Investigation and Prediction of Small Intestinal Precipitation of Poorly Soluble Drugs : a Study Involving in silico, in vitro and in vivo Assessment

    Författare :Sara Carlert; Hans Lennernäs; Bertil Abrahamsson; Patrick Augustijns; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gastrointestinal precipitation; crystallization; crystal nucleation; crystal growth; classical nucleation theory; poorly soluble drugs; drug absorption; biopharmaceutics classification system; in vitro in vivo correlations IVIVC ; in silico prediction; human intestinal fluid; dog intestinal fluid; simulated intestinal fluid; Biofarmaci; Biopharmaceutics;

    Sammanfattning : The main objectives of the present project were to increase the understanding of small intestinal precipitation of poorly soluble pharmaceutical drugs, investigate occurrence of crystalline small intestinal precipitation and effects of precipitation on absorption. The aim was to create and evaluate methods of predicting crystalline small intestinal drug precipitation using in vivo, in vitro and in silico models. LÄS MER

  5. 4. Spherical Crystallization of Benzoic Acid

    Författare :Jyothi Thati; Åke Rasmuson; Luis Moreno; Eva Blomberg; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Spherical agglomeration; Spherical agglomeration; Benzoic acid; Solubility phase diagram; Physico mechanical properties; Chemical engineering; Kemiteknik;

    Sammanfattning : Spherical agglomerates of benzoic acid crystals have been successfully prepared by drowning-out crystallization in three solvent partial miscible mixtures. Benzoic acid is dissolved in ethanol, bridging liquid is added and this mixture is fed to the agitated crystallizer containing water. LÄS MER

  7. 5. Particle Engineering by Spherical Crystallization:Mechanisms and Influence of Process Conditions

    Författare :Jyothi Thati; Åke Rasmuson; Stephane Veesler; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Spherical agglomeration; Benzoic acid; Solubility; Phase diagram; Physico- mechanical properties size distribution; particle morphology and crushing strength; elastic recovery; compressibility ; Chemical engineering; Kemiteknik;

    Sammanfattning : Spherical agglomerates of benzoic acid crystals have been successfully prepared by drowning-out crystallization in three solvent partial miscible mixtures. Benzoic acid is dissolved in ethanol, bridging liquid is added and this mixture is fed to the agitated crystallizer containing water as the anti-solvent. LÄS MER