Avancerad sökning

Hittade 5 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Drug Delivery to the Brain by Liposomes : Understanding Factors Governing Delivery Outcomes In Vivo

   Författare :Yang Hu; Margareta Hammarlund-Udenaes; Teresa Dalla Costa; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nanocarrier; liposome; blood-brain barrier; brain delivery; formulation; methotrexate; diphenhydramine; microdialysis; pharmacokinetics; model-based approach; Farmaceutisk vetenskap; Pharmaceutical Science; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

   Sammanfattning : The blood-brain barrier (BBB) is the primary obstacle for efficient drug delivery to the central nervous system (CNS). One promising strategy to enhance brain delivery is to utilize nanocarriers (NC), e.g., liposomes, encapsulating CNS drugs. LÄS MER

3. 2. Mediator synergism in mast celldependent inflammation : role of histamine for leukocyte recruitment

   Författare :Henrik Thorlacius; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Chemoattractants; dexamethasone; histamine; inflammation; intravital microscopy; mast cells; leukocyte adhesion; leukocyte rolling; microcirculation; mast cells; nitric oxide; leukotrienes; P-selectin.;

   Sammanfattning : The aim of the present thesis was to study functional interactions between histamine and chemotactic mediators, and the role of histamine for leukocyte recruitment in mast cell-dependent inflammation. Leukocyte rolling, adhesion and emigration. LÄS MER

4. 3. The fate and effect of pharmaceuticals in boreal surface waters

   Författare :Johan Fahlman; Jonatan Klaminder; Jan Karlsson; Fredrik Jutfelt; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Aquatic ecosystems; behavioural effects; ecotoxicology; acoustic telemetry; field verification; social network; ekotoxikologi; Ecotoxicology; environmental science; miljövetenskap;

   Sammanfattning : Traces of pharmaceuticals are often found in streams, rivers, and lakes as the result of effluent water discharge. This dissertation aims to create a better understanding of the fate of drugs in aquatic ecosystems and how oxazepam, an anxiolytic pharmaceutical commonly detected in surface waters, affects the behavior of perch (Perca fluviatilis). LÄS MER

5. 4. In Vivo Active Drug Uptake and Efflux at the Blood-Brain Barrier : With Focus on Drug Transport Interactions

   Författare :Muhammad Waqas Sadiq; Margareta Hammarlund-Udenaes; Sven Björkman; N. Joan Abbott; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood-brain barrier; Active uptake transport; Microdialysis; P-glycoprotein; Drug interactions; Species differences; Pharmacokinetics; Pharmacodynamics; NONMEM; Pharmaceutical Science; Farmaceutisk vetenskap;

   Sammanfattning : The blood-brain barrier (BBB) controls the movement of substances into and out of the brain. The tight junctions between endothelial cells and energy dependent transporters in the BBB influence rate and extent of drug distribution to the brain. LÄS MER

7. 5. Sub-lethal Effects of Anthropogenic Contaminants on Aquatic Invertebrates

   Författare :Warren Kunce; Frank Johansson; Jan Örberg; Sarah Josefsson; Jes Rasmussen; Uppsala universitet; []
   Nyckelord :ecotoxicology; sub-lethal; behavior; biomarkers; thermal tolerance; pesticides; pyrethroids; neonicotinoids; pharmaceuticals; antihistamines; microplastics; mixtures; freshwater; invertebrates; chironomids; damselflies; snails; Biology with specialization in Animal Conservation; Biologi med inriktning mot zoologisk bevarandebiologi;

   Sammanfattning : Anthropogenic contaminants are considered to play a substantial role in the decline of freshwater invertebrate diversity. Sub-lethal effects of many of these contaminants on behaviour and life-history traits of aquatic invertebrates may contribute to their decline. LÄS MER