Sökning: "diol ligands"
Visar resultat 1 - 5 av 7 avhandlingar innehållade orden diol ligands.
1. Synthesis and evaluation of bicyclic 1,3-diols (BODOLs) as ligands for asymmetric catalysis
Sammanfattning : Several ligands based upon 2-substituted bicyclic[2.2.2]octane-2,6-diols (BODOLs) were synthesized and evaluated in two catalytic reactions: I) the Ti(IV)-mediated catecholborane asymmetric reduction of prochiral ketones and II) as catalysts in the asymmetric addition of diethylzinc to aromatic aldehydes. LÄS MER
2. Synthesis and Applications of P-chirogenic Phosphine Boranes
Sammanfattning : AbstractThis thesis reports the independent synthesis of both enantiomers of P-chirogenic phosphine ligands and the building blocks thereof, which are suitable for parallel synthesis efforts and for the generation of more diverse libraries of P-chirogenic compound. The use of P-chirogenic phosphine boranes in transition metal-catalyzed reactions, such as palladium-catalyzed allylic alkylation and amination, is also described. LÄS MER
3. Synthesis and asymmetric transformations of diols by enzyme- and ruthenium catalysis
Sammanfattning : The major part of this thesis describes the synthesis of aliphatic secondary diols and the development of lipase- and ruthenium-catalyzed asymmetric transformations of these diols. Several acyclic 1,4-diols and 1,5-diols were synthesized, and by combining a lipase-catalyzed asymmetric transformation with a ruthenium-catalyzed epimerization, enantiomerically- and diastereomerically enriched diacetates were obtained. LÄS MER
4. Synthesis and characterization of fluorescent stilbene-based probes targeting amyloid fibrils
Sammanfattning : Alzheimer’s disease (AD) is characterized by two main protein aggregate hallmarks in the brain: extracellular deposition of the amyloid-β (Aβ) in senile plaques and intracellular neurofibrillary tangles (NFTs) consisting of hyperphosphorylated tau protein. The past decade has seen great progress in the development of imaging probes for the non-invasive detection of Aβ and tau aggregates. LÄS MER
5. Expression of Manganese Lipoxygenase and Site-Directed Mutagenesis of Catalytically Important Amino Acids : Studies on Fatty Acid Dioxygenases
Sammanfattning : Polyunsaturated fatty acids can be bioactivated by two families of dioxygenases, which either contain non-heme iron (lipoxygenases) or heme (cyclooxygenases, linoleate diol synthases and α-dioxygenases).Lipoxygenases and their products play important roles in the pathophysiology of plants and fungi. LÄS MER
