Sökning: "dilated cardiomyopathy"

Visar resultat 11 - 15 av 34 avhandlingar innehållade orden dilated cardiomyopathy.

1. 11. Cellular responses to respiratory chain dysfunction

   Författare :Anna Hansson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Mitochondria; TFAM; cardiomyopathy; aging; reactive oxygen species ROS ;

   Sammanfattning : Mitochondria are network-like organelles present in most mammalian cells. They contain the respiratory chain (RC) that produces the majority of the energy needed in the cell, in the form of ATP. RC deficiency can arise due to mutations in the mitochondrial DNA (mtDNA) or in nuclear genes encoding mitochondrial proteins. LÄS MER

3. 12. From gene mutation to gene expression : studies on multiple endocrine neoplasia type 1 and vascular endothelial growth factors

   Författare :Emma Tham; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Multiple endocrine neoplasia type 1; mutation detection; Vascular Endothelial Growth Factors; recombinant protein; dilated cardiomyopathy; multiple sclerosis;

   Sammanfattning : Multiple Endocrine Neoplasia type 1, MEN1, is an inherited cancer syndrome whose gene was localised to chromosome 11q13 in 1988. A number of !candidate genes were characterised before the MEN1 gene was cloned in 1997. DNA sequencing of MEN1 to search for mutations in patients is used as a complement to clinical diagnosis. LÄS MER

4. 13. Passive volume reduction heart surgery using the Acorn CorCap cardiac support device

   Författare :Fredrik Bredin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Acorn CorCap cardiac support device; acute myocardial infarction; aortic regurgitation; dilated cardiomyopathy; heart failure; heart failure surgery; passive containment surgery; ventricular remodelling;

   Sammanfattning : Heart failure is a growing health problem, affecting an increasing number of patients with rapidly increasing costs for the health care system. In spite of recent improvements in pharmacological, non-pharmacological and surgical treatments the prognosis for patients with severe heart failure is still poor. LÄS MER

5. 14. Life without mitochondrial DNA : studies of transgenic mice

   Författare :Jianming Wang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :mitochondrial disease; mitochondrial DNA mtDNA ; mitochondrial transcripton factor A Tfam ; cre-loxP; conditional knockout; transgenic; mitochondrial cardiomyopathy; apoptosis;

   Sammanfattning : Mitochondrial DNA (mtDNA) is a closed circular DNA genome that resides in the mitochondrial network. Mutations of mtDNA cause spontaneous and hereditary disorders known as mitochondrial diseases. Mitochondrial transcription factor A (Tfam) is a key factor for transcription of mtDNA in vitro. LÄS MER

7. 15. Thyroid hormone receptor expression in cardiovascular disease and pharmacology

   Författare :Shiva Shahrara; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :TR mRNA; amiodarone; propranolol; heart rate; Quantitative RT-PCR; Western blot; Northern blot; mRNA and protein distribution; chronic valvular disease; Mated cardiomyopathy; AT- I cardiomyocytes; mouse myocardium;

   Sammanfattning : The heart is a major target organ for thyroid hormone actions. Thyroid hormone exerts effects on the myocardium, which are mediated by specific nuclear receptors. The thyroid hormone receptors (TR) are members of the steroid hormone receptor superfamily. LÄS MER