Sökning: "diketopiperazines"

Hittade 5 avhandlingar innehållade ordet diketopiperazines.

  1. 1. Synthesis of 2,5-Diketopiperazines, A Useful Scaffold in Medicinal Chemistry

    Författare :Marcus Tullberg; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :;

    Sammanfattning : .... LÄS MER

  2. 2. Synthetic studies of marine indole alkaloids and related systems

    Författare :Ann-Louise Jonsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Marine indole alkaloids; antifouling; synthesis; diketopiperazines; HWE-reaction; bis indole alkaloids; imidates; carbazole alkaloids;

    Sammanfattning : This thesis is mainly focussed oil the synthesis of marine indole alkaloids and related systems, many of which display interesting biological activities. In the first part of this thesis we could establish and confirm the stucture of barettin and 8,9dihydrobarettin, isolated from the marine sponge Geodia baretti. LÄS MER

  3. 3. Inhibition of the MDM2/p53 Interaction Design, Synthesis and Evaluation of MDM2 Inhibitors

    Författare :Mariell Pettersson; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :Protein-protein interactionProtein-protein interaction; MDM2 p53 interaction; MDM2 inhibitors; α- helix mimetics; β-hairpin; 2; 5-diketopiperazine; spiro-2; 5-diketopiperazine; purine; 8- triazolyl purine; solution conformational analysis; NAMFIS; fluorescence;

    Sammanfattning : Numerous essential cellular processes are regulated by protein-protein interactions (PPIs) and PPIs have therefore been recognised as potential new drug targets. The transcription factor p53 is often referred to as the guardian of the genome due to its involvement in DNA repair, induction of cell cycle arrest and cellular apoptosis. LÄS MER

  4. 4. Genomics and metabolomics in the North Atlantic deep-sea sponge Geodia barretti

    Författare :Karin Steffen; Paco Cárdenas; Ulf Göransson; Anders Backlund; Susanna López-Legentil; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES; demosponge; whole genome sequencing; population genetics; peptide synthesis; Farmakognosi; Pharmacognosy;

    Sammanfattning : Sponges are among the earliest diverging taxa in the animal tree of life. They are sessile, filter-feeding animals found in marine and freshwater habitats. Many species are characterized by a close, specific and consistent association with microbes, mainly Bacteria and Archaea. LÄS MER

  5. 5. Protein and lipid interactions of mammalian antibacterial peptides

    Författare :Yuqin Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Gene-encoded antibacterial peptides are multifunctional effector molecules and play an important role in host innate immunity. Upon stimulation, the mature active peptides are released from inactive precursors. LÄS MER