Sökning: "digital readout"

Visar resultat 16 - 20 av 32 avhandlingar innehållade orden digital readout.

1. 16. Development and Application of Proximity Assays for Proteome Analysis in Medicine

   Författare :Felipe Marques Souza de Oliveira; Masood Kamali-Moghaddam; Ulf Landegren; Mats Gullberg; Janne Lehtiö; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Solid-phase proximity ligation assay; post-translational modifications; glycosylation; phosphorylation; Enzyme-linked immunosorbent assay; immunoassay and rolling circle amplification; Proximity Extension Assay; inflammation protein biomarkers; autoantibodies; autoimmune disease;

   Sammanfattning : Along with proteins, a myriad of different molecular biomarkers, such as post-translational modifications and autoantibodies, could be used in an attempt to improve disease detection and progression. In this thesis, I build on several iterations of the proximity ligation assay to develop and apply new adaptable methods to facilitate detection of proteins, autoantibodies and post-translational modifications. LÄS MER

3. 17. Proximity Ligation Assays for Disease Biomarkers Analysis

   Författare :Rachel Yuan Nong; Ulf Landegren; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proximity ligation assay; blood biomarkers; protein interactions; pathway analysis; single molecule; next-generation sequencing; Molekylär medicin; Molecular Medicine;

   Sammanfattning : One of the pressing needs in the field of disease biomarker discovery is new technologies that could allow high performance protein analysis in different types of clinical material, such as blood and solid tissues. This thesis includes four approaches that address important limitations of current technologies, thus enabling highly sensitive, specific and parallel protein measurements. LÄS MER

4. 18. Method development for the analysis of protein interactions

   Författare :Despoina Kermpatsou; Ola Söderberg; Maréne Landström; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; in situ; proximity ligation assay PLA ; strand displacement; proximity-dependent initiation of hybridisation chain reaction proxHCR ; protein complexes; rolling circle amplification RCA ; MolBoolean; vitamin D; 1; 25D3-MARRS receptor; PDIA3; ERp57; CYP24A1; c-Myc; prostate cancer; Molekylär cellbiologi; Molecular Cellbiology; Molekylär medicin; Molecular Medicine;

   Sammanfattning : Biological processes take place through interactions between macromolecules, such as nucleic acids and proteins. It is, therefore, fundamental to understand the functions of proteins and how they form complexes in order to carry out their role. LÄS MER

5. 19. Ultra-wideband Millimeter-wave Antenna Arrays and Front-end Systems : For high data rate 5G and high energy physics applications

   Författare :Imran Aziz; Dragos Dancila; Ville Viikari; Uppsala universitet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

   Sammanfattning : The demand for wireless data communications is rapidly increasing due to several factors including increased internet access, increasingly growing number of mobile users and services, implementation of the Internet of Things (IoT), high-definition (HD) video streaming and video calling. To meet the bandwidth requirement of new and emerging applications, it is necessary to move from the existing microwave bands towards millimeter-wave bands. LÄS MER

7. 20. Single-Molecule Detection and Optical Scanning in Miniaturized Formats

   Författare :Jonas Melin; Fredrik Nikolajeff; Mats Nilsson; Hugh Fan; Uppsala universitet; []
   Nyckelord :Biotechnology; microfluidics; single-molecule detection; MOEMS; μTAS; lab-on-a-chip; RCA; thermoplastics; injection molding; hot embossing; Bioteknik;

   Sammanfattning : In later years polymer replication techniques have become a frequently employed fabrication method for microfluidic and micro-optical devices. This thesis describes applications and further developments of microstructures replicated in polymer materials. LÄS MER