Sökning: "digital quantification"

Visar resultat 1 - 5 av 154 avhandlingar innehållade orden digital quantification.

1. 1. Single Molecule Detection : Microfluidic Automation and Digital Quantification

   Författare :Malte Kühnemund; Mats Nilsson; Ulf Landegren; Sten Linnarsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; single molecule; digital; rolling circle amplification; magnetic particle; padlock probe; microfluidics; resistive pulse sensing; lab on chip; mobile phone microscopy; enrichment; sequencing;

   Sammanfattning : Much of recent progress in medical research and diagnostics has been enabled through the advances in molecular analysis technologies, which now permit the detection and analysis of single molecules with high sensitivity and specificity. Assay sensitivity is fundamentally limited by the efficiency of the detection method used for read-out. LÄS MER

3. 2. Homicide Injury Quantification : Measures of injury severity in homicide victims and associations with homicide characteristics

   Författare :Fredrik Tamsen; Ingemar Thiblin; Peter Mygind Leth; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Homicide; Injury score; Injury quantification; Offender profiling; Rättsmedicin; Forensic Medicine;

   Sammanfattning : Some previous studies have found that the amount and severity of injuries in homicide victims correlate with different homicide characteristics, such as the victim-offender relationship and drug influence of the offender. If such relationships exist, they may be used by homicide investigators as part of an offender profiling. LÄS MER

4. 3. Digital Electrical DNA Sensing

   Författare :Maoxiang Guo; Wouter van der Wijngaart; Fredrik Westerlund; KTH; []
   Nyckelord :DNA detection; thiol-ene-epoxy; rolling circle amplification; digital measurement; DNA stretching; microwell-array; gold nanowires; electrical measurement; specificity; limit of detection; liquid storage; disease diagnosis; lab-on-a-chip; point-of-care.;

   Sammanfattning : Molecule detection is a workhorse in life sciences and medicine, for example in cancer diagnosis and virus and bacterial detection. DNA analysis can provide vital information about the state of a host organism and its medical and health condition. LÄS MER

5. 4. Multiscale Methods and Uncertainty Quantification

   Författare :Daniel Elfverson; Axel Målqvist; Frédéric Legoll; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; multiscale methods; finite element method; discontinuous Galerkin; Petrov-Galerkin; a priori; a posteriori; complex geometry; uncertainty quantification; multilevel Monte Carlo; failure probability; Beräkningsvetenskap med inriktning mot numerisk analys; Scientific Computing with specialization in Numerical Analysis;

   Sammanfattning : In this thesis we consider two great challenges in computer simulations of partial differential equations: multiscale data, varying over multiple scales in space and time, and data uncertainty, due to lack of or inexact measurements.We develop a multiscale method based on a coarse scale correction, using localized fine scale computations. LÄS MER

7. 5. Image Analysis Methods and Tools for Digital Histopathology Applications Relevant to Breast Cancer Diagnosis

   Författare :Andreas Kårsnäs; Robin Strand; Carolina Wählby; Ewert Bengtsson; Anant Madabhushi; Uppsala universitet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; image analysis; breast cancer diagnosis; digital histopathology; immunohistochemistry; biomarker quantification; Computerized Image Processing; Datoriserad bildbehandling;

   Sammanfattning : In 2012, more than 1.6 million new cases of breast cancer were diagnosed and about half a million women died of breast cancer. The incidence has increased in the developing world. The mortality, however, has decreased. LÄS MER