Sökning: "digital microfluidics"

Visar resultat 1 - 5 av 37 avhandlingar innehållade orden digital microfluidics.

1. 1. Single Molecule Detection : Microfluidic Automation and Digital Quantification

   Författare :Malte Kühnemund; Mats Nilsson; Ulf Landegren; Sten Linnarsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; single molecule; digital; rolling circle amplification; magnetic particle; padlock probe; microfluidics; resistive pulse sensing; lab on chip; mobile phone microscopy; enrichment; sequencing;

   Sammanfattning : Much of recent progress in medical research and diagnostics has been enabled through the advances in molecular analysis technologies, which now permit the detection and analysis of single molecules with high sensitivity and specificity. Assay sensitivity is fundamentally limited by the efficiency of the detection method used for read-out. LÄS MER

3. 2. Microfluidics in Surface Modified PDMS : Towards Miniaturized Diagnostic Tools

   Författare :Sara Thorslund; Fredrik Nikolajeff; Jonas Bergquist; Elisabeth Verpoorte; Uppsala universitet; []
   Nyckelord :Materials science; µTAS; micro total analysis system; PDMS; poly dimethylsiloxane ; microfluidics; heparin; blood filtration; on-chip; ESI-MS; desalting; QCM-D; biocompatible; CD4; capillary flow; lab-on-chip; microfabrication; enrichment; point-of-care; hydrophilic; oxidation; Materialvetenskap;

   Sammanfattning : There is a strong trend in fabricating miniaturized total analytical systems, µTAS, for various biochemical and cell biology applications. These miniaturized systems could e.g. gain better separation performances, be faster, consume less expensive reagents and be used for studies that are difficult to access in the macro world. LÄS MER

4. 3. Microfluidic Compartmentalization for Smart Materials, Medical Diagnostics and Cell Therapy

   Författare :Emre Iseri; Wouter van der Wijngaart; Nicole Pamme; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Microfluidics; microfabrication; compartmentalization; partitioning; droplet microfluidics; self-assembly; 3D microarrays; soft composites; beads; particles; core-shell particle; point-of-care; diagnostics; dipstick; digital bioassays; lab-on-a-chip; urinary tract infection; bacteria detection; E. coli; cell encapsulation; hydrogel; cell therapy; spider silk; magnetic metamaterials.; Mikrofluidik; mikrotillverkning; kompartmentalisering; partitionering; droppmikrofluidik; självmontering; 3D-mikromatriser; mjuka kompositer; pärlor; partiklar; kärna-skalpartikel; vårdpunkt; diagnostik; mätsticka; digitala bioanalyser; laboration-a-chip; urinvägsinfektion; bakteriedetektering; E. coli; cellinkapsling; hydrogel; cellterapi; spindelsilke; magnetiska metamaterial.;

   Sammanfattning : The organisation of fluids in small compartments is ubiquitous in nature, such as in the cellular composition of all life. This work explores several engineering avenues where microscale fluid compartmentalization can bring novel material properties or novel functionality in life sciences or medicine. LÄS MER

5. 4. Microfluidics and AI for single-cell microbiology

   Författare :Praneeth Karempudi; Johan Elf; Yoav Shechtman; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Microfluidics; Artificial intelligence; Deep learning; Single-cell microbiology; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

   Sammanfattning : Most of the biological sciences deal with understanding the relationships between phenotypes and the underlying molecular mechanisms of organisms. This thesis is an engineering, computational, and experimental exercise in expanding the scope and scale of phenotype-genotype mapping techniques in single-cell microbiology using microscopy, microfluidics, and image processing. LÄS MER

7. 5. Digital holography and image processing methods for applications in biophysics

   Författare :Hanqing Zhang; Magnus Andersson; Krister Wiklund; Wählby Carolina; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Digital holographic microscopy; image processing; image reconstruction; bacterial adhesion; cell morphology; algorithm development; software design; quantitative measurement; microfluidics; multidisciplinary research; signalbehandling; Signal Processing; teknisk fysik med inriktningen mikrosystemteknik; engineering science with specialization in microsystems technology;

   Sammanfattning : Understanding dynamic mechanisms, morphology and behavior of bacteria are important to develop new therapeutics to cure diseases. For example, bacterial adhesion mechanisms are prerequisites for initiation of infections and for several bacterial strains this adhesion process is mediated by adhesive surface organelles, also known as fimbriae. LÄS MER