Sökning: "digital bioassay"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden digital bioassay.

1. 1. Phylogenies and Secondary Chemistry in Arnica (Asteraceae)

   Författare :Catarina Ekenäs; Katarina Andreasen; Anders Backlund; Lynn Bohs; Uppsala universitet; []
   Nyckelord :Biology; phylogeny; ITS; ETS; RPB2; sesquiterpene lactones; PCA; bioassay; NF-κB; neutrophil; chloroplast; Biologi; Arnica; Asteraceae;

   Sammanfattning : The genus Arnica (Asteraceae) was investigated for phylogenetic relationships and sesquiterpene lactone (STL) content with the aims to trace the evolutionary history of the genus and to investigate possible congruencies between DNA sequence data, secondary chemistry, and biological activity. Complex evolutionary patterns in Arnica are evident from phylogenetic analyses of chloroplast regions (the rpl16 and rps16 introns and the psbA–trnH, ycf4–cemA, and trnT–L spacers), nuclear ribosomal regions (the internal and external transcribed spacers) and the nuclear low-copy DNA region coding for the second largest subunit of RNA polymerase II (RPB2) between exons 17 and 23. LÄS MER

3. 2. Thiol-ene Nanostructuring

   Författare :Reza Zandi Shafagh; Klas Tommy Haraldsson; Wouter van der Wijngaart; Niels Bent Larsen; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Nanostructuring; thiol-ene; OSTE; electron beam lithography EBL ; reaction injection molding RIM ; nanoimprint lithography NIL ; BioNEMS; QCM; digital bioassay; protein patterning; Lab-on-a-chip; polymer;

   Sammanfattning : Improving the health and well-being of humankind does not only constitutepart of our moral codes, but is also enlisted as the number three goal ofthe 2030 agenda for sustainable development set by the UN. Fulfilling suchobjective in the regions of resource-poor settings or for age groups with morevulnerability to infectious agents demands immediate actions. LÄS MER

4. 3. Mistletoes and Thionins : as Selection Models in Natural Products Drug Discovery

   Författare :Sonny Larsson; Anders Backlund; Lars Bohlin; Peter J. Houghton; Uppsala universitet; []
   Nyckelord :Pharmacognosy; drug discovery; mistletoe; phylogeny; cytotoxic peptides; Santalales; Farmakognosi;

   Sammanfattning : The process of drug discovery from natural products starts with the selection of study object. In this project recent knowledge and methods are incorporated to investigate the process of such selection for pharmacognostic investigations. LÄS MER

5. 4. Cytotoxic Compounds of Plant Origin – Biological and Chemical Diversity

   Författare :Petra Lindholm; Anders Backlund; Lars Bohlin; Kristín Ingólfsdóttir; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacognosy; pharmacognosy; cytotoxicity; antitumour; Nuphar alkaloid; cyclotide; thionin; cardiac glycoside; Farmakognosi; Pharmacognosy; Farmakognosi;

   Sammanfattning : The development of resistance by tumour cells to chemotherapeutic agents is a major problem in cancer treatments. One way to counter this is to find compounds with cytotoxic mechanisms other than those of drugs in clinical use today. LÄS MER

7. 5. Detection of Biomolecules Using Volume-Amplified Magnetic Nanobeads

   Författare :Teresa Zardán Gómez de la Torre; Maria Strømme; Peter Svedlindh; Mikkel Fougt Hansen; Uppsala universitet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Magnetic biosensor; magnetic nanobeads; Brownian relaxation; padlock probe; rolling circle amplification; DNA detection; protein detection; Engineering Science with specialization in Nanotechnology and Functional Materials; Teknisk fysik med inriktning mot nanoteknologi och funktionella material;

   Sammanfattning : This thesis describes a new approach to biomolecular analysis, called the volume-amplified magnetic nanobead detection assay (VAM-DNA). It is a sensitive, specific magnetic bioassay that offers a potential platform for the development of low-cost, easy-to-use diagnostic devices. LÄS MER