Sökning: "differentially expressed genes"
Visar resultat 1 - 5 av 236 avhandlingar innehållade orden differentially expressed genes.
1. Detection of Differentially Expressed Genes in Alzheimer's Disease : Regulator of G-protein Signalling 4: A Novel Mediator of APP Processing
Sammanfattning : Alzheimer’s disease is a neurodegenerative disease characterised by progressive memory deterioration and cognitive impairment. Pathological hallmarks are extracellular senile plaques, neurofibrillary tangles and neuron loss. Senile plaques are produced through altered processing of the membrane-bound protein APP. LÄS MER
2. From Genes to Therapy : Modeling and Novel Therapeutic Strategies for Brain Tumors
Sammanfattning : Medulloblastoma is the most common malignant pediatric brain tumor and is molecularly divided into four subgroups – WNT, SHH, Group 3 and Group 4. Two thirds of medulloblastoma patients survive, but survivors often suffer from severe, lifelong side-effects. The MYCN oncogene is deregulated in many medulloblastoma patients. LÄS MER
3. Screening for Candidate Brain Tumor Genes : Identifying Genes that Cooperate with Platelet-Derived Growth Factor in Glioma Development and Progression
Sammanfattning : Malignant primary brain tumors, gliomas, often overexpress both platelet-derived growth factor (PDGF) ligands and receptors providing an autocrine and/or paracrine boost to tumor growth. Glioblastoma multiforme (GBM) is the most frequent glioma. Its aggressive and infiltrative growth renders it extremely difficult to treat. LÄS MER
4. Human adipose tissue. Genes predominantly expressed in the visceral depot and in hypertrophic adipocytes
Sammanfattning : The obesity prevalence is increasing worldwide and obesity is closely linked to type 2 diabetes and cardiovascular disease. Both visceral fat accumulation and enlarged adipocyte size are risk factors for obesity related metabolic disorders. LÄS MER
5. Genetic studies of candidate genes in eczema
Sammanfattning : Eczema is a common inflammatory skin disorder characterised by itching and relapsing eczematous lesions. It usually presents in early childhood and affects about 10-20% of all children. The background is multifactorial, with both environmental risk factors and hereditary factors contributing to the development of the disease. LÄS MER