Sökning: "differential gene regulation"

Visar resultat 21 - 25 av 121 avhandlingar innehållade orden differential gene regulation.

  1. 21. The role of leptin in zebrafish (Danio rerio) : Novel insights into appetite regulation and reproduction

    Författare :Emmanouil Tsakoumis; Monika Schmitz; Tatjana Haitina; Åsa Wallén-Mackenzie; Ana Gómez Peris; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; zebrafish; leptin; appetite; GRN; brain; reproduction; oocyte maturation; ovulation; Biology with specialization in Comparative Physiology; Biologi med inriktning mot jämförande fysiologi;

    Sammanfattning : The hormone leptin is a peripheral metabolic signal and an important regulator of energy balance. In mammals, leptin acts on the appetite centers in the hypothalamus, causing anorexigenic functions by inhibiting food intake. It is also considered as a link between the nutritional status and the endocrine reproductive axis. LÄS MER

  3. 22. Metabolic and mitogenic transduction cascades in skeletal muscle : implications for exercise effects on glucose metabolism and gene regulation

    Författare :Mei Yu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Exercise; skeletal muscle; glucose homeostasis; insulin signal transduction; gene regulation; MAPK cascades; AMPK; MEF2-DNA binding.;

    Sammanfattning : Level of physical activity is linked to improved glucose homeostasis. The molecular signaling mechanisms by which insulin and exercise/muscle contractions lead to increased glucose transport and metabolism and gene expression have not been completely elucidated. LÄS MER

  4. 23. Activity and Regulation of Telomerase in Malignant Cells

    Författare :Anna Lindkvist; Ylva Paulsson-Karlsson; Göran Roos; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; apoptosis; ATC; c-Myc; drug sensitivity; ESCC; hTERT; hypoxia; IFN; MM; neuroblastoma; p53; telomerase; TGF-β; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

    Sammanfattning : An important step in tumorgenesis is the acquisition of cellular immortality. Tumor cells accomplish this by activating the enzyme telomerase, and thereby avoiding replicative senescence. The aim of this thesis was to study the activity and regulation of telomerase in a panel of malignant cell types. LÄS MER

  5. 24. Nephrin-mutations in congenital nephrotic syndrome of the Finnish type and cell lineage specific gene regulation

    Författare :Olga Beltcheva; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Nephrin; NPHS 1; CNF; podocytes; promoter;

    Sammanfattning : Kidneys, the main excretory organs in vertebrates, play central role in removing water soluble metabolic waste products from the organism. Many acquired and inherited renal diseases in man lead to kidney dysfunction and nephrotic syndrome - life-threatening condition affecting increasing number of people in the modem society. LÄS MER

  7. 25. Molecular regulation of microsomal triglyceride transfer protein gene, MTP : functional genetic studies in relation to cardiovascular disease

    Författare :Helena Ledmyr; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Microsomal triglyceride transfer protein; polymorphism coronary heart disease; CHD; cardiac lipid metabolism; protein function; functional promoter studies;

    Sammanfattning : The microsomal triglyceride transfer protein, MTP, is expressed mainly in the liver, intestine and in the heart. It is crucial for the assembly and secretion of apob-containing lipoproteins, chylomicrons in the intestine and very-low density lipoproteins (VLDL) in the liver. LÄS MER