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Visar resultat 1 - 5 av 121 avhandlingar som matchar ovanstående sökkriterier.
1. Contributions to Statistical Analysis of Gene Expression Data
Sammanfattning : .... LÄS MER
2. Hypoxic gene regulation and oncogenic pathways in neuroblastoma
Sammanfattning : Neuroblastoma patients show remarkable clinical heterogeneity, with courses ranging from spontaneous regression to fatal tumor progression despite intense multi-modal treatment. Previous studies have shown that hypoxia pushes neuroblastoma cells towards a more immature phenotype, which correlates to aggressive disease. LÄS MER
3. Gene expression in carcinogenesis
Sammanfattning : It is important to understand the processes of carcinogenesis and to find out which genes are involved . One way to study the process on a molecular basis is to identify differences in gene expression. LÄS MER
4. Novel endogenous mechanisms of complement regulation - A delicate balance
Sammanfattning : In this thesis, the biochemical mechanisms for complement activation by endogenous proteins are explored. The short leucine-rich repeat proteins (SLRPs) help organise extracellular matrices. We found that several SLRPs bind C1q and of these, fibromodulin and osteoadherin trigger complement. LÄS MER
5. Bioinformatics studies on the mechanisms of gene regulation in vertebrates
Sammanfattning : Gene regulation implicates an important role in organismal complexity through contributing to phenotypic variation. In my thesis, I studied three diverse components of gene regulatory networks including transcription factors, DNA methylation and microRNAs to elucidate their role in vertebrates. LÄS MER