Sökning: "dhfr gene"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden dhfr gene.

  1. 1. Avian Malaria and Related Blood Parasites: Molecular Diversity, Ecology and Evolution

    Författare :Olof Hellgren; MEMEG; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; diversity; Plasmodium; bird-migration; transmission; blackfly; host-specificity; host-preference; cytochrome b; DHFR-TS; recombination; phylogeny; Ecology; Ekologi; Genetics; cytogenetics; Genetik; cytogenetik; Parasitology human and animal ; Haemoproteus; Leucocytozoon; Parasitologi människa och djur ; Animal ecology; Djurekologi; Natural science; Naturvetenskap;

    Sammanfattning : Malaria-like parasites consist of a large group of species that infects primates, rodents, bats, lizard and birds. I have focused on parasites from the genera Haemoproteus, Plasmodium and Leucocytozoon that are infecting birds. LÄS MER

  3. 2. Drug discovery against leishmaniasis : Bio- and chemoinformatic guided strategies for target evaluation and hit identification

    Författare :Elisabet Vikeved; UCM Alsmark; Christian Sköld; David Horn; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Leishmaniasis; Drug discovery; Lateral gene transfer; Comparative genomics; Virtual screening; Target fishing; Marine natural products;

    Sammanfattning : Leishmaniasis is a neglected tropical disease mainly affecting poor people in developing countries. It is caused by infections of flagellated protozoa belonging to genus Leishmania. The few available drugs are associated with problems such as low effectiveness, severe side effects and resistance development. LÄS MER

  4. 3. Molecular diagnosis of drug resistance in Plasmodium falciparum and virulence factors in Entamoeba histolytica

    Författare :Sherwan Zindrou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Plasmodium falciparum; dhfr gene; pyrimethamine; cycloguanil; mutations; Polymerase chain reaction; Entamoeba histolytica; hemolysins; hemolysis; virulence factors.;

    Sammanfattning : Four species of the protozoan parasite genus Plasmodium are known to infect man. Plasmodium falciparum, the most virulent species is increasingly associated with resistance to antimalarial drugs. LÄS MER

  5. 4. Malaria on islands : human and parasite diversities and implications for malaria control in Vanuatu

    Författare :Akira Kaneko; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :malaria; Plasmodium falciparum; Plasmodium vivax; glucose-6-phosphate dehydrogenase deficiency; CYP2C19; dihydrofolate reductase; cycloguanil; proguanil; mass drug administration; diversity; island; Vanuatu; Pacific;

    Sammanfattning : The genetic diversities displayed by human and malaria parasites at different frequencies in different geographical areas represent a major obstacle for the development of malaria control strategies including malaria chemotherapy and malaria vaccine. We investigated some genetic diversities on Vanuatu islands with various malaria endemicities. LÄS MER

  7. 5. Characterization of resistance to quinolones, sulfonamide and trimethoprim in Campylobacter jejuni as well as to macrolides in the related bacterium, Helicobacter pylori

    Författare :Amera Gibreel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Pharmaceutical Microbiology; farmaceutisk mikrobiologi;

    Sammanfattning : Gastroenteritis caused by C. jejuni is usually a mild to moderate self-limiting disease. Treatment is recommended in some cases. In recent years, quinolones have been increasingly used to treat acute bacterial enteritis. LÄS MER