Sökning: "developmental programming"

Visar resultat 1 - 5 av 27 avhandlingar innehållade orden developmental programming.

  1. 1. Cytokines and lipids in pregnancy – effects on developmental programming and placental nutrient transfer

    Författare :Susanne Lager; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipose tissue; amino acids; cytokines; developmental programming; free fatty acids; insulin resistance; interleukin-6; lipoprotein lipase; nutrient transport; placenta; toll-like receptor 4;

    Sammanfattning : Metabolic disturbances, in particular those associated with nutritional challenges, that take place during development, both in utero and early postnatal life, have long-lasting health consequences on an individual. The most pronounced evidence of these challenges is a deviation in birth weight. LÄS MER

  3. 2. Perinatal programming and neuroendocrine function

    Författare :Cecilia Nilsson; Göteborgs universitet; []
    Nyckelord :;

    Sammanfattning : Perinatal growth and development are dependent on a sufficient metabolic, hormonal and nutritional environment. Suboptimal conditions during specific perinatal developmental windows can lead to permanent programming of physiological systems in the fetus or newborn, with implications for adult health. LÄS MER

  4. 3. Essential fatty acids in the perinatal period. Short and long term effects in a rat model

    Författare :Marina Korotkova; Göteborgs universitet; []
    Nyckelord :EFA; perinatal period; lactation; diet; adipose tissue; leptin; programming;

    Sammanfattning : Nutritional factors during a sensitive perinatal period may lead to developmental adaptations proposed to program for pathological conditions later in life. An adequate supply of essential fatty acids (EFA) during pregnancy and lactation is crucial for optimal fetal and postnatal development. LÄS MER

  5. 4. Impact of epidemiologically identified mixtures of endocrine disrupting chemicals on metabolic programming

    Författare :Polina Lizunkova; Joëlle Rüegg; Elin Engdahl; Joachim Sturve; Carl-Gustaf Bornehag; Juliette Legler; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Endocrine disrupting chemicals; Mixtures; Metabolism; Developmental Toxicology; Epigenetics; Biologi med inriktning mot ekotoxikologi; Biology with specialization in Environmental Toxicology;

    Sammanfattning : We are ubiquitously exposed to a plethora of endocrine-disrupting chemicals (EDCs), i.e. substances that alter the function(s) of the endocrine system. While ample evidence show individual EDC's influence on developmental processes resulting in adverse health outcomes, less is known about the effects of human-relevant EDC mixtures exposure. LÄS MER

  7. 5. Single-cell transcriptomic analyses of early embryonic development and developmental programming by androgen excess

    Författare :Yu Pei; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Infertility is a compelling problem an increased prevalence among couples. Although multiple causes have been hypothesized to increase the risk of infertility, changes in lifestyles and environment are the possible links to the causes. LÄS MER