Sökning: "developmental hematopoiesis"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden developmental hematopoiesis.

  1. 1. Modelling Human Developmental Hematopoiesis. Towards in vitro Generation of Human Hematopoietic Stem Cells

    Författare :Carolina Guibentif; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Human pluripotent stem cells; Embryonic Development; endothelial-to-hematopoietic transition; Hematopoiesis;

    Sammanfattning : The possibility to manufacture hematopoietic stem cells (HSCs) in the laboratory would provide an indefinite source of cells for patients requiring bone marrow transplantation. Moreover, combined with the progress in gene editing techniques, it would provide a novel platform for gene and cell replacement therapies for a range of currently incurable congenic and acquired disorders. LÄS MER

  3. 2. Long bone growth and evolution revealed by three-dimensional imaging

    Författare :Jordi Estefa; Sophie Sanchez; Per Ahlberg; Holly Woodward; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; 3D histology; hematopoiesis; humerus; tetrapods; Biologi; Biology;

    Sammanfattning : Propagation phase-contrast synchrotron radiation microtomography is a non-destructive method used for studying histology in three dimensions (3D). Using it, the 3D organization of the diaphyseal cortical vascularization in the humerus of two seymouriamorphs was analyzed in this thesis. LÄS MER

  4. 3. The Role of Lhx2 During Organogenesis : - Analysis of the Hepatic, Hematopoietic and Olfactory Systems

    Författare :Åsa Kolterud; Leif Carlsson; Stefan Thor; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; LIM-homeobox gene; Lhx2; fetal liver; hepatic stellate cells; hematopoietic stem cells; septum transversum; self-renewal; odorant receptor genes; olfactory epithelium; olfactory sensory neuron; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : During embryonic development a variety of tissues and organs such as the lung, eye, and kidney are being formed. The generation of functional organs is regulated by reciprocal cell-cell interactions. Via the secretion of soluble molecules one type of cells affect the fate of their neighboring cells. LÄS MER

  5. 4. Early fate decisions in hematopoietic stem and progenitor cells. Through the lens of genomic and functional assays

    Författare :Fatemeh Safi; Avdelningen för molekylär hematologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoiesis; HSCs; singel cell sc ; scRNA-seq; scATAC-seq; CD9; Aging;

    Sammanfattning : Hematopoietic stem cells (HSCs) are rare cells on top of the differentiation hierarchy of hematopoiesis. HSCs are unique in their combined capacity to differentiate into all mature blood lineages and self-renew to maintain the HSC pool. LÄS MER

  7. 5. Molecular and Functional Dynamics of Hematopoietic Progenitor Cell Fate During Ontogeny

    Författare :Maria Jassinskaja; Proteomisk hematologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hematopoies; developmental hematopoiesis; Proteomics; Leukemia; Mass Spectrometry;

    Sammanfattning : Hematopoietic stem and progenitor cells (HSPCs) in the fetus and the adult possess distinct molecular signatures that regulate cell fate and change their susceptibility to initiation and progression of hematological malignancies, such as leukemia. It is well established that fetal and adult hematopoiesis are functionally distinct processes; however, the underlying molecular mechanisms that govern ontogenic differences in normal and malignant hematopoiesis have thus far been poorly explored on the proteomic level. LÄS MER