Sökning: "deletion mutant"

Visar resultat 1 - 5 av 101 avhandlingar innehållade orden deletion mutant.

1. 1. Genes and Physiological Role of the Eukaryotic Nicotinamide Nucleotide Transhydrogenase

   Författare :Eva Lagberg Arkblad; Chalmers tekniska högskola; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Celegans; cDNA; gene structure; transhydrogenase; A acetabulum; expression pattern; NAD P H; deletion mutant; chromosomal localisation; methyl viologen;

   Sammanfattning : Nicotinamide nucleotide transhydrogenase (NNT, EC 1.6.1. LÄS MER

3. 2. Novel Fatty Acid Dioxygenases of Human and Plant Pathogenic Fungi : Studies by Gene Deletion and Expression

   Författare :Fredrik Jernerén; Ernst Oliw; Ivo Feussner; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; aspergilli; dioxygenase; oxygenase; Magnaporthe oryzae; Gaeumannomyces graminis; Lasiodiplodia theobromae; jasmonic acid; linoleate diol synthase; cyclooxygenase; prostaglandin H synthase; cytochrome P450; oxylipin; hydroperoxide isomerase; allene oxide synthase; Pharmaceutical pharmacology; Farmaceutisk farmakologi; Biochemical Pharmacology; Biokemisk farmakologi;

   Sammanfattning : The dioxygenase-cytochrome P450 fusion proteins (DOX-CYP) comprise a heme-containing enzyme family that shares structural and catalytic properties with mammalian prostaglandin H (PGH) synthases. 7,8-Linoleate diol synthase (7,8-LDS) of Gaeumannomyces graminis was first characterized, and DOX-CYP enzymes are of mechanistic and biological interest. LÄS MER

4. 3. Mutation profile at the hprt locus in T-cells of non-smoking males

   Författare :Anne-May Österholm; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :human T-cells; hprt mutation; in vivo; deletion; splicing; base substitution;

   Sammanfattning : Extensive studies have been done on mutations in several marker genes in order to predict health consequences such as carcinogenesis. However, more information about mutations arising in vivo in somatic cells is needed to understand the relationship between the different factors involved in mutagenesis such as DNA damage, DNA repair capacity and individual susceptibility, and to elucidate the influence of endogenous mechanisms and environmental exposures. LÄS MER

5. 4. Identification and characterisation of SMIM1 variants determining the Vel blood group

   Författare :Mikael Kronborg Christophersen; Avdelningen för hematologi och transfusionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood groups; Vel blood group system; genetic variation; transcriptional regulation;

   Sammanfattning : The Vel blood group antigen is present on red blood cells from all humans except rare Vel-negative individuals, who can form antibodies to Vel in response to transfusion or pregnancy. It was first described in 1952 as a high incidence antigen, while the molecular background was recently discovered to be a 17-bp deletion in Small Integral Membrane Protein 1, that causes a frame-shift mutation and abolishes SMIM1 expression, thus creating a Vel-negative phenotype. LÄS MER

7. 5. Neuropeptide Y (NPY) and glutamate transporter (GLAST) in behavioral models of psychiatric disorders

   Författare :Rose-Marie Karlsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : For many psychiatric disorders there are still unmet needs for treatment. Using genetically modified mice provide means to study the systems that underlie these disorders as well as identifying potential novel targets for treatment. LÄS MER