Sökning: "deleterious mutations"
Visar resultat 6 - 10 av 41 avhandlingar innehållade orden deleterious mutations.
6. Mechanisms of adaptation to the fitness cost of antibiotic resistance
Sammanfattning : The dissemination and persistence of antibiotic resistance, is not only depending on the volume of drugs used but also on the resistance mechanisms effect of bacterial fitness (reproductive ability). Fitness is a multifactorial parameter that is comprised of the relative growth rate of the resistant pathogen in the host and in the environment, as well as the clearance and transmission rates compared to susceptible strains. LÄS MER
7. Dynamics of inbreeding and genetic rescue in a small population
Sammanfattning : Isolation at small population size can reduce individual fitness and impede population growth caused by inbreeding and genetic drift (i.e. inbreeding depression). Inbreeding depression can however be circumvented by gene flow from unrelated individuals through masking of recessive deleterious alleles and contribute to population persistence (i. LÄS MER
8. Sexual conflict, sexual selection, and genetic variance in fitness
Sammanfattning : Understanding sex-specific genetic variance for fitness is of fundamental importance to our understanding of evolution. This thesis presents the findings of empirical investigations into sex-specific genetic variance in fitness. LÄS MER
9. Artificial neural networks in models of specialization and sympatric speciation
Sammanfattning : This thesis deals with specialization and how it is linked to sympatric speciation. The trait driving specialization is a cue recognition trait modelled with artificial neural networks that exploiters use to discriminate beneficial resources from detrimental resources based on the signals of the resources. LÄS MER
10. New Insights in Genetic and Epigenetic Mechanisms Involved in Parathyroid Tumorigenesis
Sammanfattning : Primary hyperparathyroidism (pHPT) is a pathology associated with one or multiple hyperfunctioning parathyroid glands. The disease prevalence occurs in roughly 1-2% of the population primarily post-menopausal women. The molecular pathology of the disease is poorly understood. LÄS MER