Sökning: "degron"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet degron.

  1. 1. Regulation of the ubiquitin-proteasome system : characterization of viral and cellular stabilization signals

    Författare :Stijn Heessen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Epstein-Barr virus EBV ; glycine-alanine GA repeat; green fluorescent protein GFP ; degron; proteasome; Rad23; ubiquitin; ubiquitin- associated UBA domain;

    Sammanfattning : The ubiquitin-proteasome system plays a fundamental role in virtually every cellular process. Degradation of endogenous proteins by this system is the major source for antigenic peptides that are presented to MHC class I-restricted cytotoxic T cells. LÄS MER

  3. 2. Studies of the chromatin form of yeast Mediator and the function of its tail module

    Författare :Miriam Nilsson; Stefan Björklund; Claes Gustafsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mediator complex; Transcriptional regulation; yeast; tail module; transcription; medicinsk biokemi; Medical Biochemistry; molekylärbiologi; Molecular Biology;

    Sammanfattning : Mediator is a large, multifunctional complex that is conserved in eukaryotes. It was first discovered in Saccharomyces cerevisiaeas required for transcriptional activators to function in a reconstituted in vitro system. Mediator is also important for stimulation of basal, unregulated transcription, and transcriptional repression. LÄS MER

  4. 3. Regulatory mechanisms of amino acid-induced signaling in Saccharomyces cerevisiae

    Författare :Deike J. Omnus; Per O. Ljungdahl; Claudio De Virgilio; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Signal transduction; regulatory mechanisms; nutrient sensing; Saccharomyces cerevisiae; Cell Biology; cellbiologi;

    Sammanfattning : This thesis describes studies aimed at elucidating the molecular mechanisms that regulate the SPS (Ssy1-Ptr3-Ssy5) signal transduction pathway in the yeast Saccharomyces cerevisiae. This pathway is induced by extracellular amino acids and facilitates their uptake. LÄS MER

  5. 4. Regulated Proteolysis: The Secrets of Lon : Cellular Roles and Stress-dependent Regulation of the Lon Protease

    Författare :Matthias J. Fink; Kristina Jonas; Axel Mogk; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Lon protease; regulated proteolysis; allosteric regulation; Caulobacter crescentus; stress responses; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Proteolysis is crucial in cells to maintain a functional proteome. It is required for removal of damaged and unfolded proteins during protein quality control, and serves as a mechanism to regulate protein levels through regulated proteolysis. LÄS MER

  7. 5. Novel Synthetic Biology Tools for Metabolic Engineering of Saccharomyces cerevisiae

    Författare :Siavash Partow; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Yeast promoter; MVA pathway; Metabolic engineering; Multi-copy plasmid.; Synthetic biology; S. cerevisiae; MEP pathway;

    Sammanfattning : The most well characterized eukaryote model organism Saccharomyces cerevisiae is not only preferred as a microbial cell factory for synthesis of industrial products, e.g. bioethanol, but this eukaryote host system is also defined as a robust scaffold for commercial production of diverse chemicals e.g. LÄS MER