Sökning: "degenerative diseases"
Visar resultat 1 - 5 av 41 avhandlingar innehållade orden degenerative diseases.
1. Neurofilament light as a marker for neurodegenerative diseases
Sammanfattning : Neurofilaments are the main cytoskeletal constituents in neuronal cells. They are belived to be important for maintaining the structural integrity and calibre of axons and dendrites thereby influencing the conduction velocity of nerve impulses. LÄS MER
2. Degenerative changes of the human temporomandibular joint : A radiological, microscopical, histomorphometrical and biochemical study
Sammanfattning : In five autopsy specimen studies human temporomandibular joints were investigated by conventional tomography, macroscopy, and microscopy for degenerative changes, in particular erosive hard-tissue changes.In the microscopical evaluation special attention was paid to the calcified cartilage. LÄS MER
3. Novel Pharmacometric Methods for Design and Analysis of Disease Progression Studies
Sammanfattning : With societies aging all around the world, the global burden of degenerative diseases is expected to increase exponentially. From the perspective drug development, degenerative diseases represent an especially challenging class. LÄS MER
4. Mitochondrial dysfunction in ageing and degenerative disease
Sammanfattning : The cytoplasm of eukaryotic cells contains a dynamic network of double-membraned organelles, called mitochondria, which perform the process of oxidative phosphorylation (OXPHOS) that provides cellular energy in the form of ATP. The respiratory chain creates an electrochemical gradient across the inner mitochondrial membrane, which drives ATP synthesis by the ATP synthase. LÄS MER
5. Cell type-specific translatome analysis of mouse models of three genetic neurodegenerative diseases
Sammanfattning : The burden neurodegenerative diseases place on patients, their loved ones, and the healthcare system is significant, and despite extensive research efforts, there is currently no cure. Since degenerative changes in the brain can begin years before symptoms appear, early intervention is critical. LÄS MER