Sökning: "defluorination."
Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet defluorination..
1. Samarium(II)-mediated Reactions in Organic Synthesis - Method Development and Mechanistic Investigation
Sammanfattning : This thesis describes the development of methods using divalent samarium reagents in organic synthesis. The main focus is placed on functional group reductions, but reductive formation of carbon-carbon bonds has also been investigated. LÄS MER
2. C1 Building Blocks: New Approaches for Thiomethylations and Esterification
Sammanfattning : The thioether motif is found in numerous pharmaceuticals. The simplest form of this motif, the methyl-thioether is similarly found in many biologically active compounds and has exhibited many advantageous properties. The installation of the thiomethyl moiety can be troublesome due to the toxicity and malodor of small sulfur reagents. LÄS MER
3. Asymmetric Hydrogenations using N, P - Ligated Iridium Complexes
Sammanfattning : The research described in this thesis focuses on the catalytic asymmetric hydrogenation of prochiral olefins using N, P – chelated iridium catalysts. This catalytic system is tolerant to a wide range of substrates and performs better than the well-known ruthenium- and rhodium-catalytic systems for substrates devoid of coordinating groups in proximity of the olefin. LÄS MER
4. Asymmetric Synthesis and Mechanistic Insights of Transition-Metal-Catalyzed Hydrogenation
Sammanfattning : The work presented in this thesis is focused on asymmetric synthesis and mechanistic insights of hydrogenations catalyzed by Ir-N,P- and Rh-diphosphine complexes. The developed methodologies provide an efficient catalytic system to access optically enriched compounds by exploiting the effect of the N,P ligand structure and investigating the enantioconvergent behavior. LÄS MER
5. Synthesis and evaluation of new PET radioloigands for imaging central norepinephrine transporters
Sammanfattning : The noradrenergic (NE), serotonergic (5-HT) and dopaminergic (DA) neurotransmission systems all have specific proteins responsible for the regulation of synaptic concentrations of neurotransmitter in the central nervous system (CNS) and in the periphery. Several reports have shown that the expression of these proteins, the monoamine transporters, within the CNS, may be altered in patients with certain neurodegenerative or neuropsychiatric disorders. LÄS MER