Sökning: "deep seq"
Visar resultat 1 - 5 av 12 avhandlingar innehållade orden deep seq.
1. Sex, Molecules, and Gene control : Ecophysiological and evolutionary aspects of key sponge species from Antarctic shallow waters and the deep sea
Sammanfattning : Very little is known about the ecophysiological aspects of Porifera (sponges) from Antarctica and North Atlantic, even though they are keystone components of these habitats. Being the earliest diverging metazoan lineage, sponges also play a fundamental role in our understanding of animal evolution. LÄS MER
2. Genome-Wide Studies of Transcriptional Regulation in Mammalian Cells
Sammanfattning : The key to the complexity of higher organisms lies not in the number of protein coding genes they carry, but rather in the intrinsic complexity of the gene regulatory networks. The major effectors of transcriptional regulation are proteins called transcription factors, and in this thesis four papers describing genome-wide studies of seven such factors are presented, together with studies on components of the chromatin and transcriptome. LÄS MER
3. Transcription regulation and growth phase transition in hyperthermoacidophilic archaea
Sammanfattning : Organisms from the domain Archaea are ubiquitously represented on our planet and encompass diverse fascinating organisms. The genus Sulfolobus belonging to the phylum Crenarchaeota including hyperthermoacidophilic strains that grow optimally at 65-85°C and pH 2-3. LÄS MER
4. Mapping and annotating the mammalian body-wide protein-coding gene expression
Sammanfattning : A central aim of fundamental research is to create conditions necessary for fueling further research and innovation. Our understanding of basic biology is central for future developments of tools for diagnosing, monitoring, and treating disease. LÄS MER
5. Measurable residual disease and clonal evolution in acute myeloid leukemia with focus on NPM1-mutations
Sammanfattning : Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults, with mutations in the NPM1 gene occurring in almost one third of all cases. The ability to detect residual leukemia below the resolution of conventional microscopy is crucial for evaluation of relapse risk after therapy. LÄS MER