Sökning: "de novo methylation"
Visar resultat 1 - 5 av 11 avhandlingar innehållade orden de novo methylation.
1. Long-range Control of Gene Expression by Imprinting Control Regions During Development and Neoplasia
Sammanfattning : Genomic imprinting is an epigenetic phenomenon by which a subset of genes is expressed in a parent of origin specific manner. Most of the imprinted genes are located in clusters. Genetic evidences suggest that genes in imprinted clusters are regulated by Imprinting Control Regions (ICRs). LÄS MER
2. Epigenetic Control of Mammalian Development : Studies on an imprinting control region
Sammanfattning : A subset of autosomal genes is preferentially or exclusively expressed from one of the parental alleles. This phenomenon, termed genomic imprinting, is highlighted by the neighboring Igf2 and H19 genes, which are monoallelically expressed on opposite parental chromosomes. These features are governed by a 2. LÄS MER
3. The Epigenome of Multiple Myeloma : From genome-wide analysis to pharmacological manipulation
Sammanfattning : Nowadays epigenetic dysregulation is known to play a crucial role in virtually all cancers. In multiple myeloma (MM), an extensively heterogeneous malignancy, the key common feature among patients is the gene silencing imposed by the PRC2 complex through the addition of H3K27me3. LÄS MER
4. DNA methylation and hypomethylating agents in high-risk myelodysplastic syndromes and acute myeloid leukemia
Sammanfattning : Epigenetic alterations are common in cancer. One example is aberrant hypermethylation of the promoters of tumor suppressor genes and hence silencing of gene expression. LÄS MER
5. Defining the role of CAAX protein proteolysis and methylation in the pathogenesis and treatment of progeria
Sammanfattning : Hutchinson-Gilford progeria syndrome (HGPS) is a rare childhood disease characterized by failure to thrive, bone abnormalities, hair loss, and a shortened life span due to cardiovascular disease, and nuclear shape abnormalities in cultured cells. HGPS is caused by de-novo mutations in LMNA, the gene encoding prelamin A. LÄS MER