Sökning: "de novo designed proteins"
Visar resultat 1 - 5 av 13 avhandlingar innehållade orden de novo designed proteins.
1. Using de novo design proteins to explore tyrosine radicals and cation-π interactions
Sammanfattning : Redox cofactors and amino-acid free radicals play important roles in biology. Although many of the same cofactors and amino acids that form these radicals are found across a broad range of biological systems, identical cofactors can have different reduction potentials. The local environment plays a role in defining these redox potentials. LÄS MER
2. Structural and Functional Studies of De Novo Designed Peptides at Surfaces
Sammanfattning : The work presented in this thesis deals with the structural and functional properties of peptides at surfaces. The interaction of peptides with surfaces is an ever so common occurrence in our every day life, from the bug squashed on the windshield of our car to the barnacle on our boat, and from the blood plasma used in the hospital to the proteins in our cells. LÄS MER
3. Prediction, Design and Determination of Protein Structures
Sammanfattning : The three-dimensional structure of protein is encoded in its amino acid sequence. Modern structure prediction algorithms make it possible to predict the structure of small proteins using sequence information alone. LÄS MER
4. Structural studies of heterogeneous amyloid species of lysozymes and de novo protein albebetin and their cytotoxicity
Sammanfattning : A number of diseases are linked to protein folding problems which lead to the deposition of insoluble protein plaques in the brain or other organs. These diseases include prion diseases such as Creutzfeld-Jakob disease, Alzheimer's disease, Parkinson's disease and type II (non-insulin dependent) diabetes. LÄS MER
5. The Design and Structure Prediction of Protein Oligomers
Sammanfattning : The minimum free energy state of a protein (the native state) is encoded by its amino-acid sequence. Due to the many torsional degrees of freedom (DOF) available to a polypeptide chain, a vast number of conformations is possible. LÄS MER