Sökning: "de novo Assembly"

Visar resultat 1 - 5 av 32 avhandlingar innehållade orden de novo Assembly.

1. 1. Protein complexes : assembly, structure and function

   Författare :Kristina Wilhelm; Ludmilla Ludmilla Morozova-Roche; Catharina Svanborg; Umeå universitet; []
   Nyckelord :HAMLET; ELOA; lysozyme; amyloid; medicinsk biokemi; Medical Biochemistry;

   Sammanfattning :  Most proteins must fold into their native conformations to fulfil their biological functions. Failure of proteins to fold leads to cell pathology and a broad range of human diseases referred to as protein misfolding disease, e.g., Alzheimer’s disease, Parkinson’s disease, and type II diabetes. LÄS MER

3. 2. Bioremediation of Toxic Metals for Protecting Human Health and the Ecosystem

   Författare :Aminur Rahman; Abul Mandal; Jana Jass; Björn Olsson; Pawel Kaszycki; Örebro universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Heavy Metals; Pollution; Accumulation; Remediation; Human Health; Bacteria; Genome Sequencing; de novo Assembly; Gene Prediction; Biology; Biologi; Bioteknik;

   Sammanfattning : Heavy metal pollutants, discharged into the ecosystem as waste by anthropogenic activities, contaminate drinking water for millions of people and animals in many regions of the world. Long term exposure to these metals, leads to several lethal diseases like cancer, keratosis, gangrene, diabetes, cardio- vascular disorders, etc. LÄS MER

4. 3. Phasing single DNA molecules with barcode linked sequencing

   Författare :David Redin; Afshin Ahmadian; Ulf Gyllensten; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Single molecule sequencing; DNA barcoding; whole genome haplotyping; linked-read sequencing; phasing; de novo genome assembly.; Biotechnology; Bioteknologi;

   Sammanfattning : Elucidation of our genetic constituents has in the past decade predominately taken the form of short-read DNA sequencing. Revolutionary technology developments have enabled vast amounts of biological information to be obtained, but from a medical standpoint it has yet to live up to the promise of associating individual genotypes to phenotypic states of wide-spread clinical relevance. LÄS MER

5. 4. Genomics of Arbuscular Mycorrhizal Fungi : Expanding knowledge, one assembly at a time

   Författare :Merce Montoliu-Nerin; Anna Rosling; Hanna Johannesson; Nicolas Corradi; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; genomics; arbuscular mycorrhizal fungi; phylogenomics; DNA; evolution; Bioinformatics; Bioinformatik; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution;

   Sammanfattning : Most life forms that inhabit Earth today are still unknown or are difficult to study. Accessing their DNA can give us information of their biology, ecology, and evolution, even when unculturable. The research here presented focused on method development for genomic research of non-model organisms. LÄS MER

7. 5. The art of transcriptome reconstruction : with applications in Picea abies (L.) H. Karst

   Författare :Karl Johan Westrin; Olof Emanuelsson; Henric Zazzi; Lukas Käll; Jens Sundström; Jarkko Salojärvi; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; transcriptome reconstruction; transcriptome assembly; transcript isoform detection; Picea abies; acrocona; cone setting; differential expression; gene families; miRNA; quality assessment; transkriptomrekonstruktion; sammansättning av transkriptom; detektering av transkriptisoform; rödgran; kottegran; kottsättning; differentiellt uttryck; genfamiljer; kvalitetsutvärdering; miRNA; Biotechnology; Bioteknologi;

   Sammanfattning : Transcriptome reconstruction is an important component in the bioinformatical part of transcriptome studies. When a reference genome is missing, highly fragmented or incomplete, a de novo transcriptome assembly is the transcriptome reconstruction approach of choice, since in such situations, a simple alignment (or mapping) would not necessarily give all theinformation concerning splice junctions, isoforms or even the full extent of the gene. LÄS MER