Sökning: "daniel single cell"
Visar resultat 1 - 5 av 20 avhandlingar innehållade orden daniel single cell.
1. Progression of RNA-sequencing to single-cell applications
Sammanfattning : New methods enable new discoveries. My time as a PhD student has run in parallel with the maturation of the RNA-seq method, and I have used it to discover basic properties of gene expression and transcriptomes. My part has been bioinformatics – the computer analysis of biological data. LÄS MER
2. Understanding and improving microbial cell factories through Large Scale Data-approaches
Sammanfattning : Since the advent of high-throughput genome sequencing methods in the mid-2000s, molecular biology has rapidly transitioned towards data-intensive science. Recent technological developments have increased the accessibility of omics experiments by decreasing the cost, while the concurrent design of new algorithms have improved the computational work-flow needed to analyse the large datasets generated. LÄS MER
3. Nerve gap repair by the use of artificial conduits and cultured cells
Sammanfattning : Peripheral nerve injuries are often associated with loss of nerve tissue and require autologous nerve grafts to provide a physical substrate for axonal growth. This thesis investigates the use of fibrin as both a tubular conduit to guide nerve regeneration and also as a matrix material to suspend various regenerative cell types within/on poly-3-hydroxybutyrate (PHB) nerve conduits. LÄS MER
4. Molecular and cellular characterization of midbrain dopaminergic neuron development
Sammanfattning : Midbrain dopaminergic (mDA) development is a complex yet highly controlled mechanistic process that is conserved across species. The understanding of these molecular details can open windows to new avenues of therapeutic medicine. Parkinson’s disease (PD) is a debilitating neurological disorder that to date has no cure or established cause. LÄS MER
5. Organization of basal ganglia circuits
Sammanfattning : Anatomical regions and how we define boundaries between and within structures in the brain put a constraint on our understanding of the brain. More than a century of research on the brain has revealed its fundamental organization to be based on single nerve cells communicating through electrical signals over chemical synapses. LÄS MER