Sökning: "damage accumulation"

Visar resultat 21 - 25 av 205 avhandlingar innehållade orden damage accumulation.

  1. 21. Regulation of G2 phase and long-term consequences of DNA damage

    Författare :Anna Won Middleton; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cell proliferation requires the accurate replication of DNA and equal segregation of replicated genes, important for maintaining the integrity of newly formed cells. At the centre of this process is a series of coordinated events termed ‘the cell cycle’, which ensures cell proliferation proceeds with high fidelity. LÄS MER

  3. 22. Protein Damage Control during Embryonic Stem Cell Differentiation: Role of the Proteasome

    Författare :Malin Hernebring; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Embryonic Stem Cells; Proteasome; Protein Carbonylation; Advanced Glycation End products; Cell Differentiation; Oxidative stress; Aging; RNAi;

    Sammanfattning : During the lifespan of organisms ranging from yeast to humans, there is an accumulation of macromolecular damage. However, these organisms produce youthful progeny with low damage levels. This thesis focuses on how this is accomplished. LÄS MER

  4. 23. Determinants of age-related brain iron accumulation and links to neurocognitive functions

    Författare :Jonatan Gustavsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Iron is crucial for development and normal functioning of the brain. With increasing age, it accumulates in the cells and can cause irreparable damage, affecting both the structure and function of the brain. Despite these findings, the factors which influence iron accumulates and the longitudinal effects of iron are still poorly understood. LÄS MER

  5. 24. Silica particle-induced NLRP3 inflammasome activation and DNA damage in respiratory epithelium

    Författare :Rongrong Wu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Respirable crystalline silica particles (CSi) can persist and induce inflammation and DNA damage in human lungs. Previous studies have used complex model systems to characterize CSi-induced DNA damage, involving co-cultures of epithelial cells and macrophages and long-term exposures, necessitating alternative models. LÄS MER

  7. 25. Oxidative Damage in Fish Used as Biomarkers in Field and Laboratory Studies

    Författare :Bethanie Carney Almroth; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; fish; oxidative stress; antioxidant enzymes; glutathione; protein carbonyls; lipid peroxidation; biomarkers; pollution; aging;

    Sammanfattning : Many toxic xenobiotics entering into the aquatic environment exert their effects through redox cycling. Oxidative stress, incorporating both antioxidant defences as well as oxidative damage, is a common effect in organisms exposed to xenobiotics in their environment. LÄS MER