Sökning: "cytotoxic mechanisms"

Visar resultat 1 - 5 av 216 avhandlingar innehållade orden cytotoxic mechanisms.

  1. 1. Studies of Cytotoxic Compounds of Natural Origin and their Mechanisms of Action

    Författare :Jenny Felth; Lars Bohlin; Joachim Gullbo; Ulf Göransson; Thomas Efferth; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytotoxic; cardiac glycoside; gambogic acid; cancer; mechanism of action; Pharmacognosy; Farmakognosi; Pharmacognosy; Farmakognosi;

    Sammanfattning : Cancer incidence is increasing and novel anticancer drugs with new mechanisms of action are essential for future chemotherapeutic treatment. Natural products have historically played an important role in the development of anti-cancer drugs and have potential to do so also in the future. LÄS MER

  3. 2. Cytotoxic mechanisms of selenium in cancer

    Författare :Eric Olm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Selenium is an essential trace element with a diverse number of functions in the body as part of multiple selenoproteins. Acknowledged for its cancer preventive properties in clinical trials, selenium has in recent years also evolved as a potential chemotherapeutic agent. LÄS MER

  4. 3. On the cytotoxic and proinflammatory properties of eosinophils

    Författare :Terese Dajotoy; Malmö Klinisk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi; bacteriology; Microbiology; CXC chemokines; inflammation; eosinophils; cytotoxic mechanisms;

    Sammanfattning : Eosinophils are multi-functional leukocytes involved in the pathophysiology of inflammatory diseases such as asthma and inflammatory bowel disease. Participation in some neoplastic diseases and in the host defense against helminths has also been postulated. They are considered both good and bad, protecting or harming the host. LÄS MER

  5. 4. Modulation of tumor sensitivity to effector mechanisms of cytotoxic lymphocytes

    Författare :Kristian Hallermalm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Tumor escape; cytotoxic lymphocytes; interferon-gamma; TNF-alpha; granzyme B; Perforin; Fas ligand;

    Sammanfattning : Today, ample evidence demonstrates a clear role for the immune system in the battle against cancer. However, the relatively high rate of mutation and proliferation of tumor cells, in combination with the selective pressure exerted by the immune system, can potentially lead to the generation of genetically altered tumor cells, which are able to evade recognition by the immune system and continue to grow and form tumors. LÄS MER

  7. 5. Nanopolysaccharide coatings for functional surfaces in water-treatment materials : From mechanisms to process scalability

    Författare :Andrea Aguilar Sánchez; Aji P. Mathew; Albert Mihranyan; Stockholms universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; nanopolysaccharides; coating; water treatment; nanocellulose; nanochitin; antifouling; antibacterial; separation technologies; materialkemi; Materials Chemistry;

    Sammanfattning : In this thesis, materials from renewable resources were used to develop functionalized surfaces for water treatment. The work is thus inspired by, and contributes to, the United Nations sustainable goals of: (i) clean water and sanitation, (ii) climate action, (iii) responsible consumption and production, (iv) life below water, and (v) partnerships for the goals. LÄS MER