Sökning: "cytotoxic T cell"

Visar resultat 1 - 5 av 260 avhandlingar innehållade orden cytotoxic T cell.

  1. 1. Deposition and Resolution of AA Amyloid

    Författare :Sofia N. Nyström; Gunilla T Westermark; Christoph Röcken; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AA-amyloid; autophagy; resolution; Morphology; cell biology; pathology; Morfologi; cellbiologi; patologi;

    Sammanfattning : Amyloidosis is a group of protein misfolding diseases characterized by extracellulardeposition of fibrillar protein aggregates. Today more than 25 different human amyloidogenicproteins have been identified, causing a variety of pathological conditions that includeAlzheimer’s disease, type 2 diabetes and prion diseases. LÄS MER

  3. 2. Adoptive T Cell Therapy of Viral Infection and Cancer : Ex vivo Expansion of Cytomegalovirus- and Prostate Antigen-specific T Cells

    Författare :Björn Carlsson; Magnus Essand; Thomas Tötterman; Malcolm Brenner; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Immunotherapy; Adoptive T cell therapy; Dendritic cell; T cell; Tetramer; Cytomegalovirus; Transplantation; pp65; Prostate cancer; TARP; Prostate antigens; Immunologi; Immunology; Immunologi;

    Sammanfattning : The main focus of my thesis has been to develop protocols for generating antigen-specific cytotoxic T lymphocytes (CTLs) and T helper cells (TH) for adoptive transfer to treat cytomegalovirus (CMV) disease and prostate cancer. CMV viremia is a severe complication in immunocompromised stem cell transplanted patients. LÄS MER

  4. 3. DNA methylation in T cell leukaemia

    Författare :Maike Bensberg; Colm Nestor; Maria Jenmalm; Sofie Degerman; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : T cell acute lymphoblastic leukaemia (T-ALL) is a predominantly paediatric cancer that stems from malignant transformation of developing T cells. While the disease has an overall survival rate of 80%, the intense chemotherapy treatment causes severe toxicity and long-term side effects. LÄS MER

  5. 4. Generating Dendritic Cells by Direct Cell Reprogramming. Merging cellular reprogramming with immunology towards the development of novel cancer immunotherapies

    Författare :Fábio Fiúza Rosa; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dendritic Cell; Direct Cell Reprogramming; Single-cell analysis; Immunotherapy;

    Sammanfattning : Cell fate reprogramming towards pluripotency or alternative somatic cell-types has highlighted the plasticity of adult somatic cells, providing new technologies to generate desired cell types for tissue repair or for disease modeling. There is momentum to bring these concepts to immunology by specifying unique immune cellular identities that set in motion immune responses. LÄS MER

  7. 5. Recognition requirements and regulatory events directing T cell responses

    Författare :Martin Gullberg; Eva-Lotta Larsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; T cell growth factor production; Lyt-2-positive T suppressor cell; Lyt-2-positive cytotoxic T lymphocytes; activation requirements of T lymphocytes; blocking of T cell functions;

    Sammanfattning : The present study has considered cellular and molecular requirements in T cell responses. The central role of T cell growth factors (TCGF) in T cell responses prompted us to study the regulatory events directing TCGF production in lectin stimulated cultures. LÄS MER