Sökning: "cytoplasmic calcium"

Visar resultat 11 - 15 av 30 avhandlingar innehållade orden cytoplasmic calcium.

  1. 11. Studies on molecular mechanisms in calcium signaling and cellular energy consumption

    Författare :Kalaiselvan Krishnan; Hjalmar Brismar; Anders Tengholm; KTH; []
    Nyckelord :ca2 signaling; ATP; PercevalHR; NKA; diabetes; Angiotensin; Biological Physics; Biologisk fysik;

    Sammanfattning : Ion signaling plays fundamental role in cell survival. Na+ and Ca2+ are critical players in ion signaling. Cells spend the major amount of energy to maintain and regulate Na+ and Ca2+ gradients across the cell membrane. Any disruption in cellular energy consumption by plasma membrane ATPases affects ion signaling and vice versa. LÄS MER

  3. 12. Parathyroid hormone-related protein (PTHrP), calcium and human osteoblast-like cells

    Författare :Jon A Tsai; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :hOB cells; PTHrP; cAMP; IGFs; IGFBPs; IL-1ß; TGF-ß; [Ca 2 ]i; [Ca2 ]O;

    Sammanfattning : Parathyroid hormone-related protein (PTHrP) may cause humoral hypercalcernia of malignancy (HHM) when overproduced by malignant tumors, but is also produced in lower amounts under normophysiological conditions in practically all cell types, including osteoblasts. One of the aims of the present study was to investigate interactions between PTHrP and osteoblasts, to elucidate bone-regulating functions of PTHrP. LÄS MER

  4. 13. A study of the cytoplasmic domains of C-CAM isoforms : calmodulin binding and phosphorylation

    Författare :Magnus Edlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :adhesion molecules; adhesion regulation; BGP; Bgp; biliary glycoprotein; Calcium; Calmodulin; CaM; CAMs; carcinoembryonic antigen gene family; C-CAM; CEA; cell adhesion; Immunoglobulin super-family; PKC; protein kinase C.;

    Sammanfattning : C-CAM, a member of the Immunoglobulin Superfamily, was originally identified as an intercellular adhesion molecule, and can mediate cell-cell adhesion by homophilic binding. However, it also appears in high concentrations in luminal, microvillar surfaces. LÄS MER

  5. 14. Molecular mechanisms involved in the generation of calcium signals in insulin secreting cells

    Författare :Kalaiselvan Krishnan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Intracellular Ca 2+ regulates diverse cellular functions in almost all the cells. In the pancreatic ß-cells, Ca 2+ signals are critical for insulin secretion. An increase in the cytoplasmic free Ca 2+ concentration ([Ca 2+ ]i) triggers insulin secretion. LÄS MER

  7. 15. On the Generation of cAMP Oscillations and Regulation of the Ca2+ Store-operated Pathway in Pancreatic Islet α- and β-cells

    Författare :Geng Tian; Erik Gylfe; Anders Tengholm; Patrick Gilon; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cAMP; oscillations; adrenaline; GLP-1; phosphodiesterase; palmitate; STIM1; Orai1; store-operated calcium entry; insulin secretion; glucagon secretion; β-cell; α-cell; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Insulin and glucagon are released in pulses from pancreatic β- and α-cells, respectively. Both cell types are electrically excitable, and elevation of the cytoplasmic Ca2+ concentration ([Ca2+]i) due to depolarization with voltage-dependent entry of the cation is the main trigger of hormone secretion. LÄS MER