Sökning: "cysteine protease inhibitor"

Visar resultat 1 - 5 av 17 avhandlingar innehållade orden cysteine protease inhibitor.

1. 1. Studies on secreted cysteine proteases of Streptococcus pyogenes : IdeS and SpeB

   Författare :Reine Vindebro; Ulrich von Pawel-Rammingen; Wolfgang Knecht; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Streptococcus pyogenes; Group A Streptococci; GAS; virulence factor; IdeS; SpeB; cysteine protease; protease inhibitor; IgG; immune evasion; molekylär bioteknik inst f molekylärbiologi ; molecular biotechnology dept of molecular biology ;

   Sammanfattning : The pathogen Streptococcus pyogenes is a significant cause of human morbidity and mortality. Most of the work in this thesis is focused on streptococcal virulence factor IdeS, but the thesis also features work on SpeB, another streptococcal virulence factor. LÄS MER

3. 2. Peptide-Based Inhibitors of Hepatitis C Virus NS3 Serine Protease: Kinetic Aspects and Inhibitor Design

   Författare :Anton Poliakov; Helena Danielson; Boris Turk; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; serine protease; inhibitor; slow-binding; protein purification; Biokemi; Biochemistry; Biokemi;

   Sammanfattning : Hepatitis C is a serious disease that affects about 200 million people worldwide. No anti-HCV vaccine or specific anti-viral drugs are available today. Non-structural protein 3 (NS3) of HCV is a bifunctional serine protease/helicase, and the protease has become a prime target in the search for anti-HCV drugs. LÄS MER

4. 3. CYSTATIN C AND NEUROENDOCRINE DIFFERENTIATION IN THE MALE REPRODUCTIVE SYSTEM AND IN PROSTATE CANCER

   Författare :Thomas Jiborn; Malmö Urologisk cancerforskning; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Urology; androgen deprivation therapy; cysteine protease inhibitor; neuroendocrine differentiation; cysteine protease; male reproductive tract; prostate cancer; nefrologi; Urologi; nephrology;

   Sammanfattning : Cystatins are endogenous protease inhibitors that regulate the proteolytic activities of family C1 (papain-like) cysteine proteases, such as human cathepsins B, H, K, L, and S. Cystatin C shows the fastest inhibition and the highest affinity of all cystatins towards lysosomal cysteine proteases in general and is widespread in human tissues and body fluids. LÄS MER

5. 4. HUMAN CYSTATIN C. Studies on structure and function of a cysteine proteinase inhibitor. Relation to hereditary cerebral haemorrhage with amyloidosis

   Författare :Magnus Abrahamson; Avdelningen för klinisk kemi och farmakologi; []
   Nyckelord :cystatin C; protein structure; amyloid-; brain health; Protease inhibitor;

   Sammanfattning : Six different cysteine proteinase inhibitors (cystatins) were isolated from human urine and characterized. Five of them... LÄS MER

7. 5. Synthesis of Novel Inhibitors of IdeS, a Bacterial Cysteine Protease Including Studies of Stereoselective Reductive Aminations

   Författare :Kristina Berggren; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cysteine protease inhibition; ; IdeS; SpeB; Papain; ; Conformational restriction; Peptidomimetics;

   Sammanfattning : Abstract The cysteine protease IdeS is an IgG degrading enzyme secreted by the bacterium Streptococcus pyogenes to evade the human immune system. In this thesis several inhibitors of IdeS have been synthesized and evaluated. Such inhibitors should be highly useful when elucidating the detailed mechanism of IdeS action. LÄS MER