Sökning: "cycloguanil"

Hittade 5 avhandlingar innehållade ordet cycloguanil.

  1. 1. Pharmacokinetics and dynamics of atovaquone and proguanil (Malarone®)

    Författare :Mita M Thapar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Malarone; Atovaquone; proguanil; cycloguanil; pharmacokinetics; drug interactions; pharmacodynamics; resistance;

    Sammanfattning : Malarone® is a fixed dose combination of atovaquone and proguanil and is mainly used for prophylaxis against P. falciparum malaria as an alternative to Lariamo® or chloroquine+proguanil. LÄS MER

  3. 2. Molecular diagnosis of drug resistance in Plasmodium falciparum and virulence factors in Entamoeba histolytica

    Författare :Sherwan Zindrou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Plasmodium falciparum; dhfr gene; pyrimethamine; cycloguanil; mutations; Polymerase chain reaction; Entamoeba histolytica; hemolysins; hemolysis; virulence factors.;

    Sammanfattning : Four species of the protozoan parasite genus Plasmodium are known to infect man. Plasmodium falciparum, the most virulent species is increasingly associated with resistance to antimalarial drugs. LÄS MER

  4. 3. Malaria on islands : human and parasite diversities and implications for malaria control in Vanuatu

    Författare :Akira Kaneko; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :malaria; Plasmodium falciparum; Plasmodium vivax; glucose-6-phosphate dehydrogenase deficiency; CYP2C19; dihydrofolate reductase; cycloguanil; proguanil; mass drug administration; diversity; island; Vanuatu; Pacific;

    Sammanfattning : The genetic diversities displayed by human and malaria parasites at different frequencies in different geographical areas represent a major obstacle for the development of malaria control strategies including malaria chemotherapy and malaria vaccine. We investigated some genetic diversities on Vanuatu islands with various malaria endemicities. LÄS MER

  5. 4. Experimental pharmacodynamic and kinetic studies related to new combination therapies against P. falciparum malaria

    Författare :Seema Gupta; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Artemisinin (ART) class of compounds are of special interest due to their rapid onset of action and high activity against multidrug resistant malaria. The major drawback in monotherapy with ART and its derivatives is the high rate of recrudescent infection. LÄS MER

  7. 5. CYP2C19 catalyzed drug metabolism in different populations

    Författare :Karin Herrlin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :CYP2C19; drug metabolism; cytochrome P450; mephenytoin; omeprazole; proguanil chloroguanide ; citalopram; debrisoquine; CYP2D6; gene duplication; pharmacogenetics;

    Sammanfattning : Metabolism catalyzed by the cytochrome P450 enzyme CYP2C19 varies between individuals, who can be either efficient (EM) or poor metabolizers (PM). In this thesis the metabolism of four different CYP2C19 substrates (citalopram, mephenytoin, omeprazole, and proguanil) was investigated in vivo in Africans (Ethiopians an Tanzanians) an in Swedish is Caucasians. LÄS MER