Sökning: "cyclization"

Visar resultat 21 - 25 av 41 avhandlingar innehållade ordet cyclization.

  1. 21. Resolution of Dynamic Systems: Applications in Asymmetric Synthesis and Materials Science

    Författare :Lei Hu; Olof Ramström; Douglas Philp; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Kemi; Chemistry;

    Sammanfattning : This thesis is built on the concepts of constitutional dynamic chemistry and dynamic kinetic resolution, where reversible covalent reactions are used to generate dynamics and kinetically controlled reactions are employed for resolution. The thesis is divided into two parts:The first section focuses on the study of dynamic systemic resolution, a concept derived from constitutional dynamic chemistry. LÄS MER

  3. 22. Development and Application ofEnzymatic Asymmetric Synthesis ofFunctionalized Alcohols

    Författare :Bin Yang; Jan-Erling Bäckvall; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The main focus of this thesis lies on enzymatic asymmetric organic reactions. In the first part ofthis work, we looked into the lipase-catalyzed transesterification and hydrolysis at the molecularlevel. LÄS MER

  4. 23. Discovery-Oriented Screening of Dynamic Systems: Combinatorial and Synthetic Applications

    Författare :Marcus Angelin; Olof Ramström; Stefan Kubik; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; chemical education; crystallization; dynamic combinatorial chemistry; dynamic combinatorial resolution; dynamic system; enzyme catalysis; isoindolinone; lipase; nitroalcohol; nitroaldol reaction; phthalide; reversible; secondary alcohol; systems chemistry; tandem reaction; Organic chemistry; Organisk kemi; Bioorganic chemistry; Bioorganisk kemi;

    Sammanfattning : This thesis is divided into six parts, all centered around the development of dynamic (i.e., reversibly interacting) systems of molecules and their applications in dynamic combinatorial chemistry (DCC) and organic synthesis. LÄS MER

  5. 24. Syntheses of some tri- and tetracyclic heterocycles containing an indole moiety

    Författare :Robert Engqvist; jan Bergman; Victor Snieckus; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Alkaloid; drug development; heterocycles; indole; metabolite; synthesis; X-ray crystallography;

    Sammanfattning : This thesis deals with the development of new synthetic methods leading to fused tri- and tetracyclic heterocycles, many of which have interesting biological activity such as antiviral and DNA intercalating properties. The reactions between isatins and 2-aminobenzylamine in acetic acid can give, depending on the conditions, either complex spirooxindoles or indolo[3,2-c]quinolin-6-ones. LÄS MER

  7. 25. Dynamic Systems : Enzymatic Synthesis, Exchange Reactions and Applications in Materials Science

    Författare :Yang Zhang; Olof Ramström; Mihail D. Barboiu; KTH; []
    Nyckelord :constitutional dynamic chemistry; reversible reactions; kinetic resolution; dynamic kinetic resolution; enzyme catalysis; lipase; asymmetric synthesis; racemization; oxazolidinone; organogel; enamine; nitroaldol reaction.;

    Sammanfattning : This thesis is divided into three parts, revolving around the developments of dynamic systems utilized in dynamic kinetic resolution (DKR) and constitutional dynamic chemistry (CDC).The first section gives an introduction to constitutional dynamics, the core concept of this thesis. LÄS MER