Sökning: "cyclisation"

Visar resultat 1 - 5 av 16 avhandlingar innehållade ordet cyclisation.

1. 1. LL-37-derived cyclic antimicrobial drug leads : Design, synthesis, activity and different ways of creating them 

   Författare :Taj Muhammad; Ulf Göransson; Sunithi Gunasekera; Adam A. Strömstedt; Wang Guangshun; Uppsala universitet; []
   Nyckelord :antimicrobial peptide; host defense; antimicrobial; LL-37; KR-12; peptide cyclisation; peptide dimerisation; croos-linking; cyanobactin-macrocyclase; PatGmac; butelase 1; enzymatic cyclisation; immobilisation; Farmakognosi; Pharmacognosy;

   Sammanfattning : In an era where last-line antibiotics are failing, one of the powerful approaches to develop novel therapeutic agents is to turn back to nature in order to identify possible drug candidates. Among the potential candidates, antimicrobial peptides (AMPs) have garnered much attention as an antimicrobial. LÄS MER

3. 2. Synthesis of Tetrahydrofuran and Pyrrolidine Derivatives Utilising Radical Reactions : Organochalcogenides in Reductive, Carbonylative and Group-Transfer Cyclisation

   Författare :Cecilia Ericsson; Lars Engman; Ilhyong Ryu; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi; Organic chemistry; Organisk kemi;

   Sammanfattning : This thesis describes free-radical reactions for the construction of tetrahydrofuran and pyrrolidine derivatives. The studies are concerned with (i) diastereoselectivity in radical cyclisation, (ii) construction of tetrahydrofuran-3-ones and pyrrolidin-3-ones via radical carbonylation/cyclisation and (iii) synthesis of tetrahydrofuran derivatives via group-transfer cyclisation of organochalcogen compounds. LÄS MER

4. 3. Design, Synthesis and Evaluation of Catalytic Chalcogenide Antioxidants

   Författare :David Shanks; Lars Engman; John C Walton; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; antioxidant; tellurium; selenium; computational design; homolytic substitution; radical cyclisation; microwave-assisted synthesis; antioxidant regeneration; Organisk kemi; Organic chemistry; Organisk kemi;

   Sammanfattning : This thesis describes the design, synthesis and evaluation of novel chalcogenide antioxidants.A computational model for the prediction of antioxidant properties of chalcogen-containing antioxidants has been developed. LÄS MER

5. 4. Synthetic development towards benzodiazepine alkaloids : total synthesis of circumdatin F and C

   Författare :Anette Witt; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Alkaloids; benzodiazepines; cyclisation; Michael reactions; quinazolinones; synthesis.;

   Sammanfattning : Benzodiazepine alkaloids exhibit a multitude of interesting pharmacological activities. This thesis deals with the development of synthetic methods towards such alkaloids, of which the main efforts can be divided into three parts. LÄS MER

7. 5. Biosynthetic and synthetic studies of the fungal metabolite galiellalactone

   Författare :Martin H Johansson; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biotechnology; Bioteknik; Organisk kemi; Organic chemistry; enzyme; mycelium; intramolecular Diels-Alder reaction; Diels-Alderase; asymmetric synthesis; biosynthesis; total synthesis; STAT3 inhibition; galiellalactone; fungal metabolite;

   Sammanfattning : Galiellalactone is a fungal metabolite found in the basidiomycetes Galiella rufa and the unidentified strain A111-95. It has been shown to possess promising activities as an inhibitor of the IL-6 mediated STAT3 signaling in HepG2 cells. LÄS MER