Sökning: "cyanine dye"

Visar resultat 1 - 5 av 17 avhandlingar innehållade orden cyanine dye.

  1. 1. Detection of Biomolecules: Syntheses and Studies of Minor Groove Binding Unsymmetrical Cyanine Dyes and Chromogenic Enzyme Substrates

    Författare :Jonas Karlsson; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; palladium-catalysed cross-couplings; optical spectroscopy; minor groove binding; DNA; cyanine dye; enzyme; intercalation; fluorescence; chromogenic;

    Sammanfattning : Visualisation or detection of biomolecules is usually achieved by the use of fluorescent or highly coloured chromophores. The work presented in this thesis deals with the development of new chromogenic substrates for the detection of enzyme activity, and new DNA-binding fluorescent dyes for staining of DNA. LÄS MER

  3. 2. Recognition and Visualization of Nucleic Acids

    Författare :Marcus Wilhelmsson; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; intercalation; cyanine dye; ruthenium; polarized spectroscopy; threading; groove-binding; kinetics; genetic screening; DNA; fluorescent base analogue;

    Sammanfattning : The work presented in this Thesis focuses on the interaction between nucleic acids and small molecules, as well as binding or incorporation of reporter chromophores into nucleic acids. The results could help in studying and understanding processes that are fundamental to describe mechanisms behind a genetic disorder. LÄS MER

  4. 3. Development and application of advanced electron microscopy techniques for materials in biological systems

    Författare :Pernilla Nevsten; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; multiple-unit drug; EFTEM; EELS; cyanine dye; SSAT; cryo-TEM; virus; TEM; apoptosis; SEM; AFm; α-TCP; apatite; XEDS; TEM grid; microscopy supports;

    Sammanfattning : Theoretically, electron microscopy and scanning probe microscopy offer information on a scale beyond the optical microscope. However, the quality of the micrograph and the obtained information is limited by the sample preparation. LÄS MER

  5. 4. Further development of light-up probes : dye synthesis and PCR applications

    Författare :Jennie Isacsson; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; asymmetric cyanine dyes; homogeneous assays; flourecent hybridisation probes; light-up probes; peptide nucleic acids; PCS; solid phase synthesis; LightUp probe;

    Sammanfattning : .... LÄS MER

  7. 5. DNA-Photosensitization by New Drugs for Photoinactivation of Viruses and Phototherapy of Tumors

    Författare :Claire Kanony; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; 7; hydroxyl radicals; singlet oxygen; 8-dihydro-8-oxo-deoxyguanosine; pyropheophorbides; electron transfer; DNA damage; hydrogen abstraction; cyanine dyes;

    Sammanfattning : Cyanines and pyropheophorbides are two classes of photoactivable dyes which are particularly interesting for photosterilization of blood used in transfusion and for treatment of localised cancers by photodynamic therapy (PDT). After a bibliographic review about the principal mechanisms of DNA photosensitization, studies about the photosensitizing properties of these two families of compounds are presented. LÄS MER