Sökning: "cultured tumor cells"

Visar resultat 1 - 5 av 110 avhandlingar innehållade orden cultured tumor cells.

  1. 1. Tumor cell heterogeneity profiling using single-cell analysis

    Författare :Emma Jonasson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tumor heterogeneity; single-cell analysis; cancer stem cells;

    Sammanfattning : Cancer is a diverse disease with large variations between tumor types and patients regarding tumor progression and prognosis. Additionally, most individual tumors are heterogeneous, containing subpopulations of cells with various characteristics. LÄS MER

  3. 2. Allogeneic dendritic cells as adjuvants in cancer immunotherapy

    Författare :Grammatiki Fotaki; Magnus Essand; Alex Karlsson-Parra; Di Yu; Tanja de Gruijl; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allogeneic dendritic cells; immune primer; adjuvant; adenoviral vector; cancer immunotherapy; tumor microenvironment; Klinisk immunologi; Clinical Immunology;

    Sammanfattning : In recent years, immunotherapeutic approaches have achieved remarkable successes through checkpoint blockade antibodies, advances in the use of chimeric antigen receptor (CAR) T cells and new insights into the immunosuppressive role of the tumor microenvironment (TME). Through the advances, the role of cancer vaccines based on ex vivo manipulated autologous dendritic cells (DC) has been challenged. LÄS MER

  4. 3. Mesenchymal Stem Cells in Tumor Growth Inhibition and Cartilage Differentiation

    Författare :Laura Varas; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicinska vetenskaper; Medicine human and vertebrates ; Medicin människa och djur ; mesenchymal stem cell; Biomedical sciences; tumor growth inhibition; FGF2; cartilage; integrin alpha11beta1; integrin alpha10beta1;

    Sammanfattning : The work presented in this thesis has been focused on mesenchymal stem cells (MSCs). In the two first studies, the effects of MSCs on tumor growth and development in vitro and in vivo was investigated. LÄS MER

  5. 4. Clinical and Experimental Studies in Peritoneal Metastases from Gastric Cancer

    Författare :Bo Hultman; Haile Mahteme; Bruno Walther; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gastric cancer; peritoneal metastases; peritoneal carcinomatosis; epidemiology; prognostic factor; survival; neoadjuvant chemotherapy; cytoreductive surgery; HIPEC; health economy; costs; systemic chemotherapy; cultured tumor cells; fluorometric analysis; cancer drug tests; chemo-sensitivity; anti tumor drugs.; Surgery; Kirurgi;

    Sammanfattning : Gastric cancer (GC) is one of leading causes of death in the world, and peritoneal metastases (PM) are a major site of recurrence. PM from GC implies a poor prognosis, with median overall survival (mOS) approximately 3 months and no survival at five years. LÄS MER

  7. 5. Hypoxia and Stem Cells in Normal and Tumor Development

    Författare :Camilla Niklasson; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; neuroblastoma; hypoxia; preclinical cancer models; ALDH; HIF-2α; PT2385;

    Sammanfattning : Neuroblastoma is a childhood malignancy of the sympathetic nervous system and accounts for 15% of all cancer-related deaths in children. To understand the biology behind neuroblastoma, clarify timing of cellular events and expression profiles of proteins preceding neuroblastoma initiation, we need more relevant preclinical models. LÄS MER