Sökning: "crypt cells"

Visar resultat 1 - 5 av 19 avhandlingar innehållade orden crypt cells.

  1. 1. Specific and nonspecific immune mechanisms in human gut : a comparative study of normal and ulcerative colitis intestine

    Författare :Moorix Mo-Wai Yeung; Sten Hammarström; Marie-Louise Hammarström; Marita Troye-Blomberg; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human intestine; ulcerative colitis; lymphoid aggregates; intraepithelial lymphocytes; lamina propria lymphocytes; γδT-cells; cytokines; IL-2; carcinoembryonic antigen; biliary glycoprotein; epithelial cells; glycocalyx;

    Sammanfattning : The intestine, with its large mucosal surface area, digests and absorbs food nutrients and maintains a beneficial microbial flora in the colon. Local protective immune responses against intestinal pathogens ensure the survival of the individual. These immune reactions are both specific and non-specific in nature. LÄS MER

  3. 2. Internal Dosimetry Development and Evaluation of Methods and Models

    Författare :Lena M Jönsson; Lund Medicinsk strålningsfysik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tomografi; Klinisk fysiologi; medical instrumentation; tomography; radiology; Clinical physics; crypt cells; intestine; radionuclide; scintillation camera; sestamibi; activity quantification; conjugate view method; Monte Carlo simulation; internal dosimetry; Nuclear medicine; radiobiology; Nukleärmedicin; radiobiologi; medicinsk instrumentering; radiologi;

    Sammanfattning : Radionuclide therapy requires patient-specific planning of the absorbed dose to target volumes, in most cases tumours, in order to achieve an expected biological effect, taking into account that the absorbed doses to normal organs and tissues should be kept as low as reasonably achievable. Therefore, the calculation of absorbed doses has to be as accurate as possible. LÄS MER

  4. 3. Patch clamp and calcium studies on human colonic mucosal cells

    Författare :Peter Sand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Human; colon crypt; HT29; K channel; Ca oscillations; volume regulation; patch clamp;

    Sammanfattning : Background: The main function of the large intestine is to fine-tune electrolyte and water balance. This is achieved through the consorted action of ion channels, transporters and pumps. Failures of this system can lead to diarrhoea. LÄS MER

  5. 4. Regulation of survival and proliferation of human intestinal epithelial cells by leukotriene D4

    Författare :Sailaja Paruchuri; Malmö Experimentell patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rac; General pathology; pathological anatomy; Patologi allmän ; patologisk anatomi; PI3K; CREB; p90RSK; Erk-1 2; PKC; inflammation; migration apoptosis; proliferation; LTD4; cell survival;

    Sammanfattning : The pro-inflammatory mediator, Leukotriene D4 (LTD4) is a product of arachidonic acid cascade and has been implicated in asthma and inflammatory bowel diseases. Prolonged inflammatory conditions like ulcerative colitis increases the risk for the development of cancer and the factors that induce the chronic immune response remain uncertain. LÄS MER

  7. 5. No guts, no glory : EphB mediated signaling in intestinal stem and progenitor cells

    Författare :Maria Genander; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The work presented in this thesis is focused on the intestinal stem cell niche, the crypts, and the Eph tyrosine kinase receptors together with their ligands that are expressed by the crypt epithelial progenitor cells. Two fundamental cellular processes, high turnover coupled to a rapid ordered migration of the newborn cells out from the crypt, characterize the normal intestine. LÄS MER