Sökning: "cryo-EM"

Visar resultat 11 - 15 av 43 avhandlingar innehållade ordet cryo-EM.

  1. 11. Tailored conjugates of N-acetylneuraminic acid and small molecules that block virus cell attachment and entry

    Författare :Emil Johansson; Mikael Elofsson; Niklas Arnberg; Geert-Jan Boons; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; N-acetylneuraminic acid; Neu5Ac; sialic acid; multivalency; Coxsackievirus A24v CVA24v ; Human adenovirus D37; D36; D26; HAdV-D37; HAdV-D26; HAdV-D36 ; 4-O-alkyl Neu5Ac; cryo-EM; branched pleconaril probes; conjunctivitis; organisk kemi; Organic Chemistry;

    Sammanfattning : Viruses are obligate intracellular parasites, unable to replicate without exploiting machinery andmaterials from host cells. Pandemics of viral diseases have had large impacts on human socieities and are continued threats to global health. LÄS MER

  3. 12. Combining low resolution, high resolution, functional, and simulation techniques : In the study of pentameric ligand-gated ion channels

    Författare :Marie Lycksell; Erik Lindahl; Kresten Lindorff-Larsen; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Neutrons; Small-angle scattering; Cryo-EM; Simulations; Ion channels; Biophysics; biofysik;

    Sammanfattning : Combining methods yielding different information is a powerful approach for understanding structural biology in general, and in particular systems such as pentameric ligand-gated ion channels (pLGICs). Pentameric ligand-gated ion channels are membrane proteins that sense chemical signals, which they convert to changes in membrane potential. LÄS MER

  4. 13. Small Particles with Big Impact : Structural Studies of Viruses and Toxicological Studies of Nanodiamonds

    Författare :Anna Munke; Marvin Seibert; Kenta Okamoto; Filipe Maia; Inger Andersson; Nicola Stonehouse; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Chaetenuissarnavirus II; cryo-EM; CtenRNAV-II; Escherichia coli; Danio rerio; flash X-ray imaging; Marnaviridae; single-particle analysis; single-particle imaging; Sogarnavirus; virus evolution; virus structure; XFEL; zebrafish embryo; Physics with specialization in Biophysics; Fysik med inriktning mot biofysik;

    Sammanfattning : Nanoparticles (NPs) can be found everywhere and their existence has both beneficial and harmful consequences for the environment and living beings. The investigations on which this thesis is based upon have contributed to an increased understanding of some of these particles and to the development of a method that could be used to study their structure. LÄS MER

  5. 14. Structural Decorations in Viruses : Unraveling Acquired Functional Structures in Icosahedral RNA Virus Capsids

    Författare :Han Wang; Kenta Okamoto; Sarah Butcher; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Viruses; RNA viruses; capsid; structure; cryo-EM; Molekylär biovetenskap; Molecular Life Sciences;

    Sammanfattning : Viruses have a profound impact worldwide, posing challenges to animal welfare, agriculture, human health, and the ecosystem. This thesis examines the realm of non-enveloped icosahedral double-stranded (ds)RNA and single-stranded (ss)RNA viruses through three studies. LÄS MER

  7. 15. Glucose and glycerol transport in adipocytes from a structural perspective

    Författare :Peng Huang; Medicinsk strukturbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipocytes; glucose and glycerol metabolism; glucose transporters; aquaglyceroporins; glucose transporter 4; aquaglyceroporin 7; protein and protein interaction; structure; single particle cryo-EM;

    Sammanfattning : Adipocytes are crucial energy reservoirs to maintain metabolic homeostasis of glucose and lipids in the human body.Glucose transporters (GLUTs) and aquaporins (AQPs) play an important role in metabolic regulation of glucose andlipids in human adipocytes. LÄS MER