Sökning: "crosses"

Visar resultat 16 - 20 av 96 avhandlingar innehållade ordet crosses.

1. 16. Genetic dissection of multifactorial disease models in the rat

   Författare :Hong Jiao; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Type 2 daibetes; Goto-Kakizaki rat; linkage analysis; quantitative trait locus; gene-gene interaction; mitochondrial sequence; parent-of-origin;

   Sammanfattning : Type 2 diabetes (T2D) is characterized by two apparently distinct pathophysiologic defects - insulin resistance and a failure of the pancreatic Beta-cells to compensate for this resistance by appropriately increasing insulin secretion. There is strong evidence for an important role of genetics in both of these components. LÄS MER

3. 17. Recombination frequencies in hybrid females of inbred lines of Drosophila melanogaster

   Författare :Staffan Lake; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : The intention of the present study was to examine the effect of the maternal genome and cytoplasm, of the attachment of extra heterochromatin of the transposing of heterochromatic regions into euchromatic parts and of temperature shocks during various stages of the development on recombination in Drosophila metanogaster. The access to marker genes along the X-chromosome induced in the inbred line made it possible to examine this array of different conditions in females with an isogenic background. LÄS MER

4. 18. Functional genomics of diapause in two temperate butterflies

   Författare :Peter Pruisscher; Karl Gotthard; Dieter Ebert; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; diapause induction; adaptation; genomics; transcriptomics; populationsgenetik; Population Genetics;

   Sammanfattning : Natural selection will act on a given phenotype to maximize fitness in a particular environment, even if this would result in reduced fitness in other environments. In insects some of the strongest selection pressures act on timing life cycles to seasonal variation in environmental conditions, in order to maximize growth, reproduction, and to anticipate the onset of winter. LÄS MER

5. 19. Two Optimization Problems in Genetics : Multi-dimensional QTL Analysis and Haplotype Inference

   Författare :Carl Nettelblad; Sverker Holmgren; José M. Álvarez-Castro; Jukka Corander; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; quantitative trait loci; genome-wide association studies; hidden Markov models; numerical optimization; linkage analysis; haplotype inference; genotype imputation; high performance computing;

   Sammanfattning : The existence of new technologies, implemented in efficient platforms and workflows has made massive genotyping available to all fields of biology and medicine. Genetic analyses are no longer dominated by experimental work in laboratories, but rather the interpretation of the resulting data. LÄS MER

7. 20. Catching the Spore killers : Genomic conflict and genome evolution in Neurospora

   Författare :Jesper Svedberg; Hanna Johannesson; Mark A. Kirkpatrick; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Genomics; genomic conflict; genome evolution; meiotic drive; spore killer; suppression of recombination; inversions; fungi; Neurospora; Biologi; Biology;

   Sammanfattning : A genome is shaped by many different forces. Recombination can for instance both create and maintain genetic diversity, but the need to locally reduce recombination rates will also leave specific signatures. LÄS MER