Sökning: "cross-tolerance"
Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet cross-tolerance.
1. Intracellular regulation of TLR signaling Basic mechanisms and importance in intestinal inflammation
Sammanfattning : Toll-like receptors (TLRs) recognize conserved structures on/in microorganisms. The intracellular signalling pathways of TLRs are shared with IL-1R and IL-18R and their activation leads to transcription of proinflammatory cytokines and type-I interferons. LÄS MER
2. The analgesic mechanisms of buprenorphine
Sammanfattning : Buprenorphine, a derivative of thebaine, is a semi-synthetic opiate and a partial p-opioid receptor agonist. Buprenorphine is also a weak kappa-opioid receptor antagonist. Buprenorphine is used clinically as an analgesic and for maintenance therapy of opiate-dependent subjects because it produces limited withdrawal symptoms. LÄS MER
3. Genetic differences in neuropathy and opioid responses in rats
Sammanfattning : The studies examined mechanisms and treatments of experimental neuropathic pain with particular emphasis on the differences between rat strains and sub-strains in basal nociceptive sensitivity, development of neuropathic behaviors and sensitivity to opioid analgesia. In order to study the mechanisms that mediate mechanical allodynia (touch-evoked pain) following ischemic nerve injury to the sciatic nerve in rats, the myelinated primary afferents have been examined in the injured and intact nerves. LÄS MER
4. Impact of Mycobacterium tuberculosis and HIV-1 on innate immune mechanisms
Sammanfattning : Human immunodeficiency virus type 1 (HIV-1), a causative agent of acquired immunodeficiency syndrome (AIDS), and Mycobacterium tuberculosis (Mtb), a causative agent of tuberculosis (TB), are among the leading causes of death from infectious disease worldwide. Interplay between HIV-1 and Mtb leads to the detrimental dysregulation of immune system mechanisms, which provides the conditions facilitating progression of the disease in co-infected individuals. LÄS MER
5. Nitric oxide generation from nitroglycerin and other no-donors measured in the lung and studies on nitrate tolerance in the cardiovascular system
Sammanfattning : Nitroglycerin (GTN) and compounds referred to as nitrovasodilators or NOdonors are frequently used in the treatment of ischemic heart disease. The common mode of action for these drugs is liberation of nitric oxide (NO). Nitric oxide evokes relaxation of smooth muscle through activation of guanylate cyclase with subsequent formation of eGMP. LÄS MER