Sökning: "cross-species"

Visar resultat 1 - 5 av 22 avhandlingar innehållade ordet cross-species.

  1. 1. Integrative Modeling of Epigenetic Regulation in Human Disease

    Författare :Xi Lu; Xingqi Chen; Chandrasekhar Kanduri; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioblastoma; Cross-species; Glioblastoma stem cell; Dravet syndrome; ATAC-seq; Single-cell multi-omics technology;

    Sammanfattning : Glioblastoma is the most common and aggressive primary brain tumor. Standard of treatment prove ineffective, leading to tumor recurrence and an average survival rate of 14 months. This treatment resistance is attributed to both inter-tumor and intra-tumor heterogeneity observed across diverse tumor samples and within individual cells. LÄS MER

  3. 2. Ontogenetic and comparative aspects of cerebellar and motor development

    Författare :Maria Christensson; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurologi; neurophysiology; Neurology; neuropsychology; Medicine human and vertebrates ; time-translation; cross-species; cerebellum; motor adaptation; development; ferret; external granular layer; neuropsykologi; neurofysiologi; Medicin människa och djur ;

    Sammanfattning : During the course of development the motor repertoire of animals and humans alike go through dramatic changes. New motor patterns arise; movements become coordinated, improve in precision and are at the same time continuously calibrated to the changing body dimensions. The cerebellum is critical for movement coordination and adaptation in adults. LÄS MER

  4. 3. Modeling and investigations of high-grade glioma to understand tumorigenesis and heterogeneity

    Författare :Nagaprathyusha Maturi; Lene Uhrbom; Helena Carén; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioblastoma; diffuse pediatric-type high-grade glioma; cell of origin; heterogeneity; serum culture; glioblastoma stem cell; chromatin accessibility; cross-species conservation; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Sammanfattning : Glioblastoma (GBM) is the most common primary malignant brain tumor. As per 2021 WHO classification, the corresponding diagnosis in children is called diffuse pediatric-type high-grade glioma (pHGG). In both cases tumors are histone 3 (H3) and isocitrate dehydrogenase 1/2 (IDH1/2) wildtype (wt). LÄS MER

  5. 4. Wild rodents as carriers of potential pathogens to pigs, chickens and humans : with special emphasis on Brachyspira spp. and Yersinia enterocolitica

    Författare :Annette Backhans; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : The aim of this thesis was to investigate the specific risks that rodents constitute for proliferation of pathogens and transmission of those to farm animals, and indirectly to humans. Rodents were captured in pig and chicken flocks, in wastewater treatment plants and other urban environments. LÄS MER

  7. 5. The dimensions of human and murine CD8 T lymphocyte diversity

    Författare :Anthonie Johan Zwijnenburg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The adaptive immune system generates and maintains a pool of CD8+ T cells with an almost limitless specificity with the purpose of maintaining homeostasis. Upon antigen encounter, CD8+ T cells undergo functional diversification and give rise to daughter cells. LÄS MER