Sökning: "cre-loxP"
Visar resultat 16 - 20 av 20 avhandlingar innehållade ordet cre-loxP.
16. VEGF-B in islet of langerhans : role in vascular signaling and lipid handling
Sammanfattning : The discovery of Vascular endothelial growth factor (VEGF)-B’s role in endothelial fatty acid uptake and tissue lipid accumulation opened a new arena for exploration of VEGF-B in lipid metabolism. Indeed, later studies demonstrated the beneficial/therapeutic effects of reducing VEGF-B signaling systemically. LÄS MER
17. Genetic and functional studies on the thyroid hormone axis
Sammanfattning : This thesis has two main parts. The first is based on the first three papers with a focus on understanding the etiology and pathogenesis of thyroid malfunction and its effects on different organs. LÄS MER
18. Molecular and Cellular Control of Palate Development in the Mouse
Sammanfattning : The formation of a definitive secondary palate in mammals is a multistep process that comprises growth, elevation, contact and fusion of the two palatal shelves. Disruption at any step generates cleft palate, a major congenital birth defect. Therefore, it is important to understand the mechanisms governing normal palate development. LÄS MER
19. Intracellular signaling in the lung : a role for C/EBP transcription factors in chronic obstructive pulmonary disease, glucocorticoid signaling and lung development
Sammanfattning : Over the last decade, a previously unknown role has been established for members of the C/EBP transcription factor family in lung gene expression. In other organs, C/EBPs are well known regulators of cell differentiation and linked processes such as proliferation, apoptosis, gene expression as well as central regulators of inflammatory responses and infectious defenses. LÄS MER
20. Central Nervous System and Innate Immune Mechanisms for Inflammation- and Cancer-induced Anorexia
Sammanfattning : Anyone who has experienced influenza or a bacterial infection knows what it means to be ill. Apart from feeling feverish, experiencing aching joints and muscles, you lose the desire to eat. Anorexia, defined as loss of appetite or persistent satiety leading to reduced energy intake, is a hallmark of acute inflammatory disease. LÄS MER