Sökning: "cortisol TNFα hierarchical modelling turnover model pharmacokinetic pharmacodynamic modelling"

Hittade 1 avhandling innehållade orden cortisol TNFα hierarchical modelling turnover model pharmacokinetic pharmacodynamic modelling.

1. 1. Modelling of drug-effect on time-varying biomarkers

   Författare :Felix Held; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; cortisol; TNFα; hierarchical modelling; turnover model; pharmacokinetic pharmacodynamic modelling; cortisol TNFα hierarchical modelling turnover model pharmacokinetic pharmacodynamic modelling;

   Sammanfattning : Model-based quantification of drug effect is an efficient tool during pre-clinical and clinical phases of drug trials. Mathematical modelling can lead to improved understanding of the underlying biological mechanisms, help in finding shortcomings of experimental design and suggest improvements, or be an effective tool in simulation-based analyses. LÄS MER