Sökning: "cortical projection neurons"
Visar resultat 1 - 5 av 18 avhandlingar innehållade orden cortical projection neurons.
1. Generation of cortical neurons through reprogramming technology
Sammanfattning : The human cortex is affected by several debilitating acute and chronic neurodegenerative disorders such as stroke, traumatic brain injury, amyotrophic lateral sclerosis and Alzheimer’s disease, which target specific types of cortical neurons. Emerging evidence indicates that stem cells and reprogrammed cells can be used to generate human cortical neurons both for cell replacement by transplantation, and for disease modeling and drug screening. LÄS MER
2. Phenotypic Specification of Striatal Progenitors; Evidence for both cell-autonomous and environmental control as studied by transplantation into the adult and developing rodent brain
Sammanfattning : The striatum is the major component of the ventral telencephalon and basal ganglia, involved in the processing of cortical information. The vast majority of the neuronal population in the striatum are striatal projection neurons, with connection to the globus pallidus and substantia nigra. LÄS MER
3. Spatial and temporal regulation of neural stem cells in the developing brain by PRDM16
Sammanfattning : The mammalian brain comprises a large number and diversity of neurons and non-neural cells. Most of these cell types derive from a single sheet of neuroepithelium (NE) that contains a limited pool of neural stem cells (NSCs). NSCs in the developing brain are under complex regulation to achieve maximum daughter cell type diversity. LÄS MER
4. The role of striatal inhibition in the processing of cortical neuronal avalanches
Sammanfattning : The brain is spontaneously active even in the absence of any obvious motor actions or sensory perceptions. This so-called resting activity or ongoing activity reflects the myriads of neuronal interactions necessary for the brain to process past actions, allow for current inputs, and prepare for future decisions and responses. LÄS MER
5. Modeling receptor induced signaling in MSNs : Interaction between molecules involved in striatal synaptic plasticity
Sammanfattning : Basal Ganglia are evolutionarily conserved brain nuclei involved in several physiologically important animal behaviors like motor control and reward learning. Striatum, which is the input nuclei of basal ganglia, integrates inputs from several neurons, like cortical and thalamic glutamatergic input and local GABAergic inputs. LÄS MER