Sökning: "cooperative binding"

Visar resultat 11 - 15 av 50 avhandlingar innehållade orden cooperative binding.

1. 11. Structural and functional studies of microsomal glutathione transferase 1

   Författare :Peter J Holm; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Glutathione transferase; membrane protein; three-dimensional structure; elecron crystallography; hydrophobic binding stoichiometry; H D exchange mass spectrometry;

   Sammanfattning : The microsomal glutathione transferase 1 (MGST1) is present in high amounts in the endoplasmic reticulum (ER) as an integral homo-trimeric membrane protein with a molecular weight of 51.9 kDa. LÄS MER

3. 12. Biological and Biophysical Studies on Ruthenium Complexes

   Författare :Anna Mårtensson; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metal susceptibility; DNA; antimicrobial; circular dichroism; ruthenium complex; linear dichroism; isothermal titration calorimetry; intercalation;

   Sammanfattning : Small molecules that interact with DNA through intercalation are attractive candidates for treatments against cancer and microbial infections. Octahedral ruthenium(II) polypyridyl complexes, being substitution-inert, readily synthesized and coordinately saturated, has the potential of being developed in to a new family of drugs. LÄS MER

4. 13. Transcription factor effects on chromatin organisation and gene regulation

   Författare :Per-Henrik Holmqvist; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Chromatin; enhanceosome; MMTV; GR; NF1; Oct1; FoxA;

   Sammanfattning : The intranuclear DNA of all eukaryotic cells is packed into chromatin, generating a repressive environment for the genome. Remodelling of the local chromatin structure is a vital process that allows access to the obscured DNA sequence and may induce the expression of specific genes. LÄS MER

5. 14. Nucleosome positioning : impact on transcription factors access

   Författare :Qiao Li; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :glucocorticoid receptor; transcription factor; gene regulation; nucleosome; nucleosome positioning; DNA-bending sequence;

   Sammanfattning : In the eukaryotic cell nucleus, DNA is organized into nucleosomes. Some of the regulatory regions are integrated into sequence-specifically positioned nucleosomes. LÄS MER

7. 15. Towards the Rational Design of Molecularly Imprinted Polymers

   Författare :Håkan S Andersson; Ann-Christin Koch-Schmidt; Ian A Nicholls; Klaus Mosbach; Richard F Venn; Tillämpad biokemi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Thermodynamics; Molecular Recognition; Polyvalency; Cooperativity; Electrostatic Interactions; Hydrophobic Effect; Chromatography; Frontal Analysis; HPLC; Spectroscopy; Molecularly Imprinted Polymer; Molecular Imprinting; Crown Ether; Template Polymerisation; Cyclodextrin; Biochemistry; Metabolism; Biokemi; Biotechnology; Bioteknik; molecular recognition; Biokemi;

   Sammanfattning : Molecular imprinting is a technique by which polymeric materials selective for a given target molecule can be created through a casting procedure. Functionalised monomers are added to a solution of molecular templates. LÄS MER