Sökning: "constitutive nitric oxide synthase cNOS"
Visar resultat 1 - 5 av 6 avhandlingar innehållade orden constitutive nitric oxide synthase cNOS.
1. Nitric oxide in experimental sepsis
Sammanfattning : Nitric oxide (NO) is important in the control of blood pressure and organ perfusion. In septic shock, NO produced by inducible NO-synthase (NOS) has been claimed to mediate pathological vasodilation and cell injury, while NO produced by constitutive NOS may be protective in counteracting hypoperfusion and organ injury. LÄS MER
2. Islet constitutive nitric oxide synthase and nitric oxide production. Modulatory effects on insulin and glucagon secretion
Sammanfattning : The aim of this thesis was to elucidate the role of nitric oxide (NO) in the transduction signalling of insulin and glucagon release by stimulating or inhibiting islet endogenous NO-production as well as by using NO donors. Insulin release stimulated by L-arginine, the substrate for constitutive NO-synthase (cNOS)-catalyzed NO-production, was increased by the selective NOS-inhibitor NG-nitro-L-arginine methyl ester (L-NAME) and suppressed by the intracellular NO donor hydroxylamine. LÄS MER
3. Nitric Oxide Synthase in Pancreatic Islets During Trauma and Parenteral Feeding
Sammanfattning : The influence of trauma (acute pancreatitis) or total parenteral nutrition (TPN) on pancreatic islet hormone secretion in relation to islet expression of inducible nitric oxide synthase (iNOS) was investigated. Acute pancreatitis resulted in an impaired glucose-stimulated insulin secretion (GSIS) which was found to be parallelled by a marked expression of iNOS and an exaggerated NO production in the pancreatic islets. LÄS MER
4. Nitric oxide (NO) and carbon monoxide (CO): A novel class of messenger molecules regulating insulin and glucagon secretion
Sammanfattning : During the last decade it has been shown that nitric oxide (NO) and carbon monoxide (CO) are produced in our own body, and that they constitute a novel class of messenger molecules. In 1992 a constitutive NO-producing NO-synthase (cNOS) was found in the islets of Langerhans, and in 1997 we could show for the first time that the islets also contained a CO-producing constitutive heme oxygenase (HO-2). LÄS MER
5. Studies on effects of antioxidants on arterial thrombosis and endothelial cell injury : With special reference to Tocopherols and ApoA1 Milano
Sammanfattning : Coronary arterial endothelial injury and thrombosis are believed to be critical factors in the pathogenesis of coronary artery disease (CAD). Experimental studies have provided evidence for au inverse relation between acute coronary events and antioxidant intake. LÄS MER