Sökning: "consistent application"

Visar resultat 6 - 10 av 195 avhandlingar innehållade orden consistent application.

  1. 6. Intracellular unbound drug concentrations : Methodology and application for understanding cellular drug exposure

    Författare :André Mateus; Per Artursson; Pär Matsson; José A. G. Morais; Jeff Krise; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intracellular unbound drug concentrations; free drug; drug binding; drug transport; drug accumulation; cellular drug response; drug target engagement; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : Most known drug targets and metabolizing enzymes are located inside cells. Interactions with these proteins are determined by intracellular unbound drug concentrations. Assessing intracellular drug exposure is technically challenging, but essential for predicting pharmacokinetic, pharmacological, and toxicological profiles of new drugs. LÄS MER

  3. 7. Towards a Multi-OS Architecture for Consistent User Interface Experience

    Författare :Tobias Holstein; Gordana Dodig-Crnkovic; Christian Berger; Elina Vartiainen; Manh Tien Tran; Mälardalens högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Computer Science; datavetenskap;

    Sammanfattning : Vehicles have greatly changed over the last decades. Originally, they were used as a means of transportation, and their drivers were solely engaged in the driving task. In modern cars the user, i.e. LÄS MER

  4. 8. Numerical simulations of long spark gaps – lightning attachment and its application

    Författare :Liliana Arévalo Gonzalez; Uppsala universitet; []
    Nyckelord :TECHNOLOGY; TEKNIKVETENSKAP;

    Sammanfattning : The Licenciate Thesis presented here is a research work on numerical simulations of two different electrical phenomena: Long gap discharges under switching impulses and the lightning attachment process of positive upward leaders. The development of a positive upward leader and the process of progress of a discharge in long gaps are composed of two intertwined physical phenomena, namely the leader channel and the corona zone. LÄS MER

  5. 9. Integrative approaches in ecotoxicological testing: Implications for biomarker development and application

    Författare :Sara Furuhagen; Elena Gorokhova; Magnus Breitholtz; Lars Förlin; Ann-Kristin Eriksson Wiklund; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biomarker; oxidative stress; Daphnia magna; Applied Environmental Science; tillämpad miljövetenskap;

    Sammanfattning : Ecotoxicology aims to understand toxic effects of chemicals in the environment. Effects can be observed at different levels of the biological organization, from molecular to ecosystem level. LÄS MER

  7. 10. Standardization and application of quantitative PCR methods in patients with hematological malignancies

    Författare :Maria Malec; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Polymerase chain reaction; RQ-PCR; Minimal Residual Disease; Acute leukemia; Hodgkin s Lymphoma; cytokines;

    Sammanfattning : Using modem combination chemotherapy regimens, it has been possible to increase the rate of complete remission (CR) in acute lymphoblastic (ALL) and acute myeloid leukemia (AML). The major reason for treatment failure in acute leukemia (AL) is the resistance of leukemic blasts to chemotherapeutic agents, which is accompanied by an inability of the immune system to eradicate residual leukemic cells surviving initial treatment. LÄS MER