Sökning: "conformational"

Visar resultat 1 - 5 av 468 avhandlingar innehållade ordet conformational.

1. 1. Conformational Stability!? : Synthesis and Conformational Studies of Unnatural Backbone Modified Peptides

   Författare :Anna S. Norgren; Per I. Arvidsson; Norbert Sewald; Uppsala universitet; []
   Nyckelord :Organic chemistry; Conformational investigations; β-peptides; glycosylation; biomolecular recognition; cyclic β³-peptides; cyclic mixed α β²-peptides; β-peptoids; Organisk kemi;

   Sammanfattning : The beauty of the wide functionality of proteins and peptides in Nature is determined by their ability to adopt three-dimensional structures. This thesis describes artificial molecules developed to mimic secondary structures similar to those found crucial for biological activities. LÄS MER

3. 2. Susceptibility genes in conformational diseases

   Författare :Malin von Otter; Göteborgs universitet; []
   Nyckelord :Conformational disease; Alzheimer’s disease; Parkinson’s disease; Cataract Protein aggregation; Cellular transport; Oxidative stress; Susceptibility; genes; SNP; Haplotype;

   Sammanfattning : Conformational diseases are characterized by protein misfolding and aggregation in the affected tissue. The aim of this thesis was to find genetic support for mechanisms in common for three prevalent ... LÄS MER

4. 3. Asymmetric Catalysis : Ligand Design and Conformational Studies

   Författare :Kristina Hallman; KTH; []
   Nyckelord :asymmetric catalysis; chiral ligand; oxazolines; conformational study; allylic substitution; polymer-bound ligands; dendritic ligands; crown ether; oxidations; palladacycle;

   Sammanfattning : This thesis deals with the design of ligands for efficientasymmetric catalysis and studies of the conformation of theligands in the catalytically active complexes. All ligandsdeveloped contain chiral oxazoline heterocycles. LÄS MER

5. 4. Assembling and Unraveling Carbohydrates Structures : Conformational analysis of synthesized branched oligosaccharides

   Författare :Thibault Angles d'Ortoli; Göran Widmalm; Christian Marcus Pedersen; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Convergent carbohydrate synthesis; Super-armed donors; Glycosylation; Conformational analysis; NMR; Chemical shift prediction; organisk kemi; Organic Chemistry;

   Sammanfattning : Advances in the elaboration of vaccines and enzyme inhibitors rely on acquiring more knowledge about protein-carbohydrate binding events. Furthermore, the relationships between biological function and the three-dimensional properties of large glycans can be studied by focusing on the structural components they contained, namely, by scaling down the system under analysis. LÄS MER

7. 5. Deciphering Carbohydrate Structure : From NMR Chemical Shifts to Conformational Analysis

   Författare :Kevin M. Dorst; Göran Widmalm; Martina Delbianco; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NMR chemical shift prediction; Structural elucidation; Conformational studies; NMR spectroscopy; MD simulations; Organic Chemistry; organisk kemi;

   Sammanfattning : Carbohydrates are ubiquitous in nature and exhibit a multitude of roles. Besides nucleic and amino acids, they can be regarded as the third alphabet of life. They are used as energy source to fuel the cells, as structural building blocks and play a key role in cellular recognition processes. LÄS MER